This review summarizes our current knowledge about the organization, structure, expression, and evolution of the class II genes in the major histocompatibility complex (MHC) of the mouse. Class II genes code for highly polymorphic cell surface molecules, called class II antigens or Ia antigens. ...
In the same manner, we calculated the MHC-II expression score based on Cd74, H2-Aa and H2-Ab1. To identify differentially expressed genes in the T cell neighborhoods, we calculated 50 nearest neighbors of every T cell based on two-dimensional spatial coordinates of cell centroids. We then ...
This recognition depends on CD4+ T cells and their direct interaction with surface-expressed MHC class II molecules complexed with antigen. We have developed a series of mouse lines that do not express mouse FIX or mouse MHC II, but instead express human FIX genes and humanized MHC II. The ...
We harnessed ZeST mice to perform single-cell RNA sequencing (scRNA-seq) for the five DC types, on index sorting from the spleen of animals either infected or not infected with MCMV, using the gating strategy shown in Fig.3band the FB5P-seq (FACS-based 5′-end scRNA-seq) protocol27,28...
HLA genes are highly polymorphic, allowing them to fine-tune the adaptive immune response. HLAs corresponding to MHC class I (HLA-A, B, and C) present small peptide antigens from inside the cell, approximately 8 to 10 amino acids in length, to CD8+ T lymphocytes in order to activate ...
(H) EMR2 not defined in mouse CD314 NKG2D, KLRK1 42kD Type II lectin-like receptor NK, CD8+ activated, not CD4+ in the periphery, macact binds MHC class I, Rae1 & ULBP4, cytolysis and cytokine production; costimulator...
(H) EMR2 not defined in mouse CD314 NKG2D, KLRK1 42kD Type II lectin-like receptor NK, CD8+ activated, not CD4+ in the periphery, macact binds MHC class I, Rae1 & ULBP4, cytolysis and cytokine production; costimulatory CD315 CD9P1, SMAP6, FPRP, PTGFRN 135kD IgSF B subset, ...
HLA genes are highly polymorphic, allowing them to fine-tune the adaptive immune response. HLAs corresponding to MHC class I (HLA-A, B, and C) present small peptide antigens from inside the cell, approximately 8 to 10 amino acids in l...
(H) EMR2 not defined in mouse CD314 NKG2D, KLRK1 42kD Type II lectin-like receptor NK, CD8+ activated, not CD4+ in the periphery, macact binds MHC class I, Rae1 & ULBP4, cytolysis and cytokine production; costimulator...
The Chemokine Receptor CX3CR1 Mediates Homing of MHC class II-Positive Cells to the Normal Mouse Corneal Epithelium 热度: Characterization and Evolution of MHC Class II B Genes in Ardeid Birds 热度: transport of streptococcus pneumoniae capsular polysaccharide in mhc class ii tubules ...