Entrez Gene ID:(Mouse) 14960,(Mouse) 14961,(Mouse) 14969 功能 protein bindingpeptide antigen bindingprotein heterodimerization activitytranscription factor bindingtoxic substance bindingubiquitin protein ligase bindingrepressing transcription factor bindingmajor histocompatibility complex protein ...
蛋白别名:histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DR alpha chain; MHC cell surface glycoprotein; MHC class II antigen DRA 基因别名:HLA-DRA; HLA-DRA1; MLRW UniProt ID:(Human) P01903 Entrez Gene ID:(Human) 3122 ...
CONCLUSIONS: The lack of induction of MHC class II genes in response to IFN-γ in trophoblast cells is caused neither by the absence of factors that bind class II promoters, nor by a lesion in the IFN-γ signaling pathway, but results from a specific inhibition of the CIITA gene. 展开 ...
We have studied the temporal variation (1999–2007) in the MHC class II DQA gene and 8 microsatellites across 8 cohorts in a population of brown hare (Lepus europaeus) from eastern Austria. Our results show no significant temporal changes in allele frequencies both in microsatellites and the DQA...
MHC class II, tumour necrosis factor , and lymphotoxin gene haplotype associations with serological subsets of systemic lupus erythematosus MHC class II, tumour necrosis factor a, and lymphotoxin a gene haplotype associations with serological subsets of systemic lupus erythematosus Ann Rheum ... Mc...
MHC Class II Gene Expression MHCclass II gene expression is controlled by the master regulator class II MHC transactivator (CIITA), with expression restricted to antigen-presenting cells and some thymic epithelial cells (Steimle et al., 1994). The expression of CIITA is tightly regulated, ensuring...
We also found that gene conversion had a stronger role in shaping the evolution of MHC class II than class I. Overall, the combination of strong positive (balancing) selection and frequent gene conversion has maintained higher diversity of MHC class II than class I in prairie grouse. This is...
M. Regulation of MHC class II gene expression by the class II transactivator. Nature Rev. Immunol. 5, 793–806 (2005). Article CAS Google Scholar Smith, M. A. et al. Positive regulatory domain I (PRDM1) and IRF8/Pu.1 counter-regulate MHC class II transactivator (CIITA) expression ...
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 en...
was held together with a bootstrap support of 65, and separated from the other two known marsupial lineages DBB and DCB as well as from the eutherian and prototherian MHC II β gene lineages. However, the topology of β gene lineages was not supported by high bootstrap values....