HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). The alpha chain gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 enc...
Entrez Gene ID:(Dog) 474861,(Dog) 474862,(Dog) 474860 功能 major histocompatibility complex protein 参与通路 adaptive immune responseantigen processing and presentation of peptide or polysaccharide antigen via MHC class II 性能保障 只要您发现Invitrogen抗体在实验中的表现与网站或说明书的所...
This complex gene-expression profile is controlled almost exclusively by a single master regulatory factor, which is known as the class II transactivator. As we discuss here, differential activation of the three independent promoters that drive expression of the gene encoding the class II ...
Structural basis for mouse LAG3 interactions with the MHC class II molecule I-Ab Lymphocyte activation gene-3 (LAG3) is an immune checkpoint protein recently approved as a target for anti-melanoma therapy. Here, the authors solve the structure of mouse LAG3 bound to MHC-II to show that LAG...
查看其他23个MHC Class II (I-Ab)抗体 说明书 实验方案 技术支持 货号12-5320-80 CNY887.00 有货 查看价格 批量或定制请求 说明书 实验方案 技术支持 抗体检测数据 (1) 已发表图片 (6) Application Created with Sketch. 图:1/7 MHC Class II I-Ab Antibody (12-5320-80) in Flow ...
1. The gene sequence not only lays the foundation for research of effect of fish immune globulin in humoral immunity and further research of mechanism of fish immune globulin humoral response, but also purified protein with biological activity can be obtained by virtue of the gene sequence, and ...
MHC Class II Gene Expression MHC class II gene expression is controlled by the master regulator class II MHC transactivator (CIITA), with expression restricted to antigen-presenting cells and some thymic epithelial cells (Steimle et al., 1994). The expression of CIITA is tightly regulated, ensuri...
We have studied the temporal variation (1999–2007) in the MHC class II DQA gene and 8 microsatellites across 8 cohorts in a population of brown hare (Lepus europaeus) from eastern Austria. Our results show no significant temporal changes in allele frequencies both in microsatellites and the DQA...
MHC class II, tumour necrosis factor α, and lymphotoxin α gene haplotype associations with serological subsets of systemic lupus erythematosus 喜欢 0 阅读量: 34 作者: N,J,McHugh,P,Owen,B,Cox,J,Dunphy,K 摘要: Objective: To conduct a case–control study to investigate whether there are ...
Using whole transcriptome sequencing, Steidl et al. identify recurrent gene translocations in B-cell lymphomas that involve the class II transactivator CIITA, the 'master regulator' of the major histocompatibility complex. These translocations downregula