Chen's study of naturally occurring adrenergic chemicals. Although the study by Foster et al. provides scientifically sound data needed by the US Food and Drug Administration (FDA) as it...doi:10.1016/S1062-1458(97)00050-0MD Milou Daniel DriciMD Raymond L. WoosleyACC Current Journal Review...
Class III antiarrhythmic agents are characterized by their ability to prol贸ong action potential and increase refractoriness. The use of these drugs, namely, sotalol hydrochloride and amiodarone hydrochloride, is rising. Both agents are effective for treating a range of ventricular arrhythmias, and ...
A Benefit -Risk Assessment of Class III Antiarrhythmic Agents. B. Brendorp,O. Pedersen,C. Torp-Pedersen,N. Sahebzadah,L. K?ber. Drug Safety . 2002Brendorp B, Pedersen O, Torp-Pedersen C, Sahebzadah N, Kober L (2002) A benefit-risk assessment of class III antiarrhythmic agents. Drug...
Novelty: Novel propanolamine and propylamine derivatives are claimed to be Class III antiarrhythmic agents. Biology: An in vivo canine study of antiarrhythmic activity is described. Class III antiarrhythmic activity was defined as an increase in ERP (effective refractory period) without a significant ...
This invention relates to thieno tetrahydropyridine and isoquinoline derivative compounds which are useful as antiarrhythmic agents, pharmaceutical compositions comprising such compounds, novel interm
DC031050 was identified as one of the most potent compounds that demonstrated typical class III antiarrhythmic agent activity[13, 14]. However, similar to other class III antiarrhythmic agents, dofetilide exhibits general noncardiac side effects, including headache, dizziness, rash and some nervous ...
Recognition of chemicals that have Class III-a properties with the appropriate kinetics is a challenging task. However, today's microprocessors have become powerful enough to characterize the Class III kinetics. A system that fully automatically screens for effective antiarrhythmic agents is described. ...
Ibutilide is the first class III antiarrhythmic agent to rely on activation of a slow inward sodium current to prolong the action potential and effective refractory period of atrial and ventricular tissue. The drug is indicated for the rapid restoration of normal sinus rhythm in patients with ...
ChemInform Abstract: Synthesis and Biological Activity of KCB-328 and Its Analogues: Novel Class III Antiarrhythmic Agents with Little Reverse Frequency Dependence.ChemInform Abstract: Synthesis and Biological Activity of KCB-328 and Its Analogues: Novel Class III Antiarrhythmic Agents with Little Reverse ...
6) class Ⅲ antiarrhythmic agent Ⅲ类抗心律失常药 1. Aim To seek class Ⅲ antiarrhythmic agents with combinational inhibiting effect on potassium channel and β-receptor. 结论化合物1d、1e、1i、1j表现出Ⅲ类抗心律失常药物延长动作电位时程的特征,有关Ⅲ/Ⅱ复合作用的药理实验有待进行。 更多例句>...