Rate-dependence of antiarrhythmic and proarrhyth- mic properties of class I and class III antiarrhythmic drugs. Basic Res Cardiol 1998;93(Suppl. 1):125-132.Weirich J, Antoni H. Rate-dependence of antiarrhythmic and proarrhythmic properties of class I and class III antiarrhythmic drugs. Basic ...
The circles placed over each structure show the chemical moieties that are unique to each of these three drugs. Regarding safety analysis using the combination of structure-based drug class analysis and animal toxicity data, FDA wrote, “There are no … studies in pregnant women. However, ...
The class III drugs prolonged the sinus cycle length (SCL), QT interval and right ventricular effective refractory period (VERP), but had little effect on ventricular conduction time in the responders and non-responders. The SCL, QT interval and VERP at the three drive cycle lengths of 600, ...
The pharmacokinetics and pharmacodynamics of oral dofetilide after twice daily and three times daily dosing Aims The pharmacokinetics and pharmacodynamics of oral dofetilide, a novel, class III antiarrhythmic drug, were assessed during administration either twic... MJ Allen,DJ Nichols,SD Oliver - 《...
Flecainide had the most potent spinal antinociceptive effect (P<0.01) among these three class I antiarrhythmic drugs. Co-administration of bupivacaine with flecainide, quinidine, or mexiletine displayed an additive effect on spinal blockades of motor function and nociception. We concluded that ...
To compare the efficacy and safety of a single dose of ibutilide, a new class III antiarrhythmic drug, with that of DL-sotalol in terminating chronic atrial fibrillation or flutter in haemodynamically stable patients. Double blind, randomised study. 43 European hospitals. 308 patients (mean age...
There are a lot of drugs out there and a lot of ways to classify them. In this lesson, you'll learn four of the ways that drugs can be classified using organ systems, therapeutics, chemistry, and law. Explore our homework questions and answers library ...
However, numerous noncardiac side effects, such as nausea, drizzles and headaches, also frequently occur with the use of class III antiarrhythmic drugs. Some adverse effects outside of cardiac tissues are consistent with the observation that the class III agents have been found to act * To ...
What are cardiotonic drugs? What is the classification of aspirin? What are the three classifications of drugs? What is a loop diuretic drug? How many drug classifications are there? What is the drug classification of nicotine? What is cholinergic agonist? What is a Schedule 1 drug? What type...
Quinidine, procainamide and disopyramide are antiarrhythmic drugs in the class 1A category. These drugs have a low toxic to therapeutic ratio, and their use is associated with a number of serious adverse effects during long term therapy and life-threatening sequelae following acute overdose. ...