Three Class I antiarrhythmic drugs (class IA: quinidine, IB: mexiletine, and IC: flecainide) were tested. After they had been intrathecally injected in rats, the potencies and durations of these drugs on spinal anesthesia were recorded. Bupivacaine, a commonly used local anesthetic, and 5% ...
In conclusion, the present evidence suggests that the diarrhea caused by class I antiarrhythmic drugs such as quinidine and propafenone is a result of a reduction in basolateral K + conductance and inhibition of BK Ca channels, thereby impeding transepithelial Na + and water absorption....
Cardioprotective effects of various class I antiarrhythmic drugs in canine hearts. J Am Coll Cardiol. 1989 Jul; 14 (1):219–224.Hanaki Y, Sugiyama S, Hieda N, Taki K, Hayashi H, Ozawa T (1989) Cardioprotective effects of various class I antiarrhyth- mic drugs in canine hearts. J Am ...
Therapeutic Areas I: Central Nervous System, Pain, Metabolic Syndrome, Urology, Gastrointestinal and Cardiovascular M.J.A. Walker, P.P.S. So, in Comprehensive Medicinal Chemistry II, 2007 6.33.5.2.1.1 Class 1 antiarrhythmic drugs are all sodium channel blockers All Class 1 drugs block cardiac ...
The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers. Multiple components of cardiac Na current play a role in determining electrical excitation in the heart. Recently, the role of nonequilibrium components in... D Fedida,PMR Orth,JC Hesketh,... - ...
The role of late I and antiarrhythmic drugs in EAD formation and termination in Purkinje fibers. Multiple components of cardiac Na current play a role in determining electrical excitation in the heart. Recently, the role of nonequilibrium components in... D Fedida,PMR Orth,JC Hesketh,... - ...
Ⅲ类抗心律失常药 1. Aim To seek class Ⅲ antiarrhythmic agents with combinational inhibiting effect on potassium channel and β-receptor. 结论化合物1d、1e、1i、1j表现出Ⅲ类抗心律失常药物延长动作电位时程的特征,有关Ⅲ/Ⅱ复合作用的药理实验有待进行。 更多例句>> 补充...
A retrospective analysis of 44 patients was carried out to evaluate the efficacy of class IA antiarrhythmic drugs (and/or ), and of drugs of one or more other classes by means of 24-hour Holter recording. This study included only patients who exhibited 5000 or more ventricular premature comple...
I., editors, Atrial fibrillation, a treatable disease? pp: 59-66. Kluwer Academic Dordrecht.Allessie M, Kirchhof C. Termination of atrial fibrillation by class IC antiarrhythmic drugs, a paradox? In: Kingma JH, van Hemel NM, Lie KI, Editors. Atrial fibrillation: a treatable dis- ease?
The effects of class Ⅰ antiarrhythmi drugs on rate-dependent blockade of maxium upstroke veolocity (V_(max)) of action potential were analysed by a microcomputer experimental system BES-2(2). The techniques of linking, module and optimization were used in program design. The differential sign...