Chapter 10. Class I and III Antiarrhythmic DrugsAn abundance of reviews on the electrophysiological basis of cardiac arrhythmias and therapeutic use of anti-arrhythmic drugs have appeared recently. The local anesthetic anti-arrhythmic drugs are class I; and the drugs that prolong action potential ...
Reprints and permissions About this article Cite this article Naccarelli, G.V., Burkman, G.M. & Hussain, S.K. Do class IC antiarrhythmics drugs need to be cast aside in atrial fibrillation patients with minimal coronary artery disease?. J Interv Card Electrophysiol 65, 347–348 (2022)....
This classification divides drug actions into class I for sodium-channel blockade (with subclasses IA, IB and IC), class II for adrenergic antagonism, class III for action-potential prolongation, and class IV for calcium-channel blockade. The development of class I drugs was curtailed when ...
All class III antiarrhythmic drugs share a common electrophysiological mechanism in that they prolong the action potential duration, and most of the drugs in this class do so primarily by inhibiting repolarizing potassium currents. Therefore, these compounds are often referred to as “potassium channel...
Summary— The pharmacodynamics of many antiarrhythmic drugs are altered by heart rate. The ability of sodium channel blockers to decrease conduction velocity (class I action) is more pronounced with rapid heart rates. Drugs with class III action increase action potential duration and refractoriness in...
Class I, sodium-channel blockers; Class II, beta-blockers; Class III, potassium-channel blockers; Class IV, calcium-channel blockers; and miscellaneous antiarrhythmics or unclassified antiarrhythmics. Class II antidysrhythmic drugs inhibit beta-adrenergic activation of adenylate cyclase and reduce sin...
Antiarrhythmic Drugs Use in Elderly Patients. Vaughan Williams Class III and IV Drugsdoi:info:doi/10.20996/1819-6446-2016-12-5-603-609E. A. UshkalovaS. K. ZyryanovK. E. ZatolochinaA. P. PereverzevN. A. ChukharevaRacionalna Farmakoterapi v Kardiologii...
class III antiarrhythmic drugsnibentanniferidylrefralonsynthesisPublications on the design, synthesis, pharmacological research, and clinical trials of the Russian original class III antiarrhythmic drugs nibentan {(RS)-4-nitro-N-[1-phenyl-5-(diethylamino)pentyl]benzamide hydrochloride} and niferidyl {...
drugselectrophysiologic effectsSummary This chapter contains section titled: Electrophysiologic Effects of Beta Blockers Beta-Blocking Agents in the Treatment of Arrhythmias Clinical Pharmacology of Beta-Blocking Agents Adverse Effects and Drug InteractionsRichard N. Fogoros M.D...
We can conclude that decreasing of I(k) may explain prolongation of cardiac repolarization induced by RG-2, and contribute to its antiarrhythmic action. 展开 关键词: class III antiarrhythmic drugs potassium current RG-2 patch-clamp DOI: 10.1067/mtc.2003.85 被引量: 2 ...