Drug Safety An International Journal of Medical Toxicology & Drug ExperienceYamreudeewong W, DeBisschop M, Martin L, Lower D. Potentially sig- nificant drug interactions of class III antiarrhythmic drugs. Drug Saf 2003; 26: 421-38.Potentially significant drug interactions of class III ...
Studies in animal models, as well as clinical experience with amiodarone and sotalol, suggest that action potential prolongation may be a useful antiarrhythmic mode of action. A number of agents that produce this class III effect are currently under development. The single greatest liability for furt...
class III antiarrhythmic drugsnibentanniferidylrefralonsynthesisPublications on the design, synthesis, pharmacological research, and clinical trials of the Russian original class III antiarrhythmic drugs nibentan {(RS)-4-nitro-N-[1-phenyl-5-(diethylamino)pentyl]benzamide hydrochloride} and niferidyl {...
Class-IV-antiarrhythmic-drug网络级抗心律失常药 网络释义 1. 级抗心律失常药 CLASS-英汉词典... ... Class III antiarrhythmic drug [医]级抗心律失常药 Class IV antiarrhythmic drug [医]级抗心律失常药 ... www.fastdict.net|基于1 个网页©
A perforated patch-clamp analysis of the effect of a novel class III antiarrhythmic agent RG-2, on voltage-dependent currents was made in rat ventricular myocytes. In these cells, RG-2 decreased delayed rectifier outward K(+) current, I(k), in concentration dependent manner with threshold conc...
The objective of this study was to investigate acute effects of the class III antiarrhythmic drug amiodarone on human K(2P)3.1 channels. Potassium currents were recorded from Xenopus oocytes using the two-microelectrode voltage clamp technique. Amiodarone produced concentration-dependent inhibition of hK...
UK-68,798, A Class III Antiarrhythmic Drug with Antifibrillatory Properties OBJECTIVE: The aim was to examine the electromechanical effects of dofetilide, a new class III antiarrhythmic agent, in isolated guinea pig ventricular mus... SC Black,BR Lucchesi - 《Cardiovascular Drug Reviews》 被引...
The very essence of any drug class analysis is a list of all of the AEs associated with all of the drugs of a given drug class. ii Toxicities Found in Animal Studies But drug class analysis was not the only source of information on bosutinib’s AEs. FDA’s Pharmacology Review detailed ...
Efficiency and safety of using the modified protocol for the administration of the domestic class III antiarrhythmic drug for the relief of paroxysmal atri... Aim:Evaluation of the efficacy and safety of the modified refralon administration protocol for the relief of paroxysmal atrial fibrillation (AF...
Class III, potassium-channel blockers; Class IV, calcium-channel blockers; and miscellaneous antiarrhythmics or unclassified antiarrhythmics. Class II antidysrhythmic drugs inhibit beta-adrenergic activation of adenylate cyclase and reduce sinoatrial node andatrioventricularnode activity. They prolongatrioventr...