Class III antiarrhythmic drugs include amiodarone, bretylium, dofetilide, ibutilide, azimilide, and dronedarone. Among these, amiodarone is the most reported one to cause adverse cutaneous reactions. Amiodarone is a lipid soluble agent which accumulates in peripheral tissues including the adipose ...
All class III antiarrhythmic drugs share a common electrophysiological mechanism in that they prolong the action potential duration, and most of the drugs in this class do so primarily by inhibiting repolarizing potassium currents. Therefore, these compounds are often referred to as “potassium channel...
class III antiarrhythmic drugsnibentanniferidylrefralonsynthesisPublications on the design, synthesis, pharmacological research, and clinical trials of the Russian original class III antiarrhythmic drugs nibentan {(RS)-4-nitro-N-[1-phenyl-5-(diethylamino)pentyl]benzamide hydrochloride} and niferidyl {...
Studies in animal models, as well as clinical experience with amiodarone and sotalol, suggest that action potential prolongation may be a useful antiarrhythmic mode of action. A number of agents that produce this class III effect are currently under development. The single greatest liability for furt...
The class III antiarrhythmic drugs have been subject to extensive clinical investigation as safer and more effective alternatives to class I drugs, which exhibit recognised risks in selected populations[5–7]. However, numerous noncardiac side effects, such as nausea, drizzles and headaches, also ...
Nattel S, Singh BN: Evolution, mechanisms, and classification of antiarrhythmic drugs: focus on Class III actions . Am J Cardiol 1999, 84 ( 9A ):11... None - 《Circulation》 被引量: 185发表: 1991年 Anticholinergic effects of class III antiarrhythmic drugs in guinea pig atrial cells. Diff...
We can conclude that decreasing of I(k) may explain prolongation of cardiac repolarization induced by RG-2, and contribute to its antiarrhythmic action. 展开 关键词: class III antiarrhythmic drugs potassium current RG-2 patch-clamp DOI: 10.1067/mtc.2003.85 被引量: 2 ...
Rate-dependence of antiarrhythmic and proarrhythmic properties of class I and class III antiarrhythmic drugs Rate or frequency-dependence is a characteristic property of antiarrhythmic drugs belonging to the Vaughan William classes I and III. The rate-dependence o... J Weirich,H Antoni - Steinkopf...
Vaughan Williams class III antiarrhythmic drugs prolong ERP with an augmented TDR which is the main mechanism of the proarrhythmic effects. Gap junctions enhancer can augment CV and diminish TDR. As a result, gap junctions enhancer combined with class III drugs may be a promising antiarrhythmic ...
In the present study the effect of landiolol, an ultra-short-acting beta(1)-selective blocker, on ES refractory to class III antiarrhythmic drugs was evaluated. METHODS AND RESULTS: The study group comprised 42 consecutive patients who developed ES for which intravenous class III antiarrhythmic ...