Class III antiarrhythmic drugs include amiodarone, bretylium, dofetilide, ibutilide, azimilide, and dronedarone. Among these, amiodarone is the most reported one to cause adverse cutaneous reactions. Amiodarone is a lipid soluble agent which accumulates in peripheral tissues including the adipose ...
All class III antiarrhythmic drugs share a common electrophysiological mechanism in that they prolong the action potential duration, and most of the drugs in this class do so primarily by inhibiting repolarizing potassium currents. Therefore, these compounds are often referred to as “potassium channel...
class III antiarrhythmic drugsnibentanniferidylrefralonsynthesisPublications on the design, synthesis, pharmacological research, and clinical trials of the Russian original class III antiarrhythmic drugs nibentan {(RS)-4-nitro-N-[1-phenyl-5-(diethylamino)pentyl]benzamide hydrochloride} and niferidyl {...
Evolution, mechanisms, and classification of antiarrhythmic drugs: Focus on class III actions. Presents a study on the evolution of antiarrhythmic drug therapy. Classification of antiarrhythmic drugs according to the system introduced by Singh and Va... Nattel,Stanley,Singh,... - 《American Journal...
Vaughan Williams class III antiarrhythmic drugs prolong ERP with an augmented TDR which is the main mechanism of the proarrhythmic effects. Gap junctions enhancer can augment CV and diminish TDR. As a result, gap junctions enhancer combined with class III drugs may be a promising antiarrhythmic ...
In the present study the effect of landiolol, an ultra-short-acting beta(1)-selective blocker, on ES refractory to class III antiarrhythmic drugs was evaluated. METHODS AND RESULTS: The study group comprised 42 consecutive patients who developed ES for which intravenous class III antiarrhythmic ...
Antiarrhythmic Drugs Use in Elderly Patients. Vaughan Williams Class III and IV Drugsdoi:info:doi/10.20996/1819-6446-2016-12-5-603-609E. A. UshkalovaS. K. ZyryanovK. E. ZatolochinaA. P. PereverzevN. A. ChukharevaRacionalna Farmakoterapi v Kardiologii...
Electrophysiologic testing was performed in 31 patients with ventricular tachycardia (21 cases) and fibrillation (10 cases) to characterize the electrophysiologic properties of patients responding or not responding to therapy with class III antiarrhythmic drugs. At the baseline, there were no differences...
Class Ic antiarrhythmic drugs are effective in the treatment of atrial fibrillation, but their mechanism of action is unknown. In previous work, we have fo... Z Wang,P Page,S Nattel - 《Circulation Research》 被引量: 424发表: 1992年 Guidelines for implantation of cardiac pacemakers and anti...
By analyzing the influence of inhibitory sulfonamide derivatives, the block phenomenology evoked by these class III antiarrhythmic drugs was studied.After isolation from their cellular environment, K+ (outw.-react.) channels became usually upregulated so that open probability increased with time to reac...