An abundance of reviews on the electrophysiological basis of cardiac arrhythmias and therapeutic use of anti-arrhythmic drugs have appeared recently. The local anesthetic anti-arrhythmic drugs are class I; and the drugs that prolong action potential duration (APD) selectively are class III drugs. ...
Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation Voigt, N (2010) Inhibition of IK, ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atri...
This classification divides drug actions into class I for sodium-channel blockade (with subclasses IA, IB and IC), class II for adrenergic antagonism, class III for action-potential prolongation, and class IV for calcium-channel blockade. The development of class I drugs was curtailed when ...
Class I and Class III Antiarrhythmic Agents: Mechanisms of Action and the Problem of Proarrhythmic Activity We investigated how modulation of L-type calcium current affects the class II antiarrhythmic effect of dofetilide. Action-potential duration (APD) was dete... V Essebag - McGill University...
The other tested class I antiarrhythmics disopyramide, mexiletine, lidocaine, and flecainide decreased Na + current by 9–13%. Procainamide and the class III antiarrhythmics N-acetylprocainamide, sotalol, ibutilide, and amiodarone were no or were very weak inhibitors of Na + absorption. Cl ...
Antiarrhythmic Drugs Use in Elderly Patients. Vaughan Williams Class III and IV Drugsdoi:info:doi/10.20996/1819-6446-2016-12-5-603-609E. A. UshkalovaS. K. ZyryanovK. E. ZatolochinaA. P. PereverzevN. A. ChukharevaRacionalna Farmakoterapi v Kardiologii...
drugselectrophysiologic effectsSummary This chapter contains section titled: Electrophysiologic Effects of Beta Blockers Beta-Blocking Agents in the Treatment of Arrhythmias Clinical Pharmacology of Beta-Blocking Agents Adverse Effects and Drug InteractionsRichard N. Fogoros M.D...
Class I, sodium-channel blockers; Class II, beta-blockers; Class III, potassium-channel blockers; Class IV, calcium-channel blockers; and miscellaneous antiarrhythmics or unclassified antiarrhythmics. Class II antidysrhythmic drugs inhibit beta-adrenergic activation of adenylate cyclase and reduce sin...
While developed as aclass III antiarrhythmic,E4031is not yet marketed for this purpose.Class III drugsprolong the repolarizing phase (phase 3) of thecardiac action potential. When given intravenously, E4031 significantly prolongs the QT and QTc intervals and, in both atrial and ventricular tissue...
We can conclude that decreasing of I(k) may explain prolongation of cardiac repolarization induced by RG-2, and contribute to its antiarrhythmic action. 展开 关键词: class III antiarrhythmic drugs potassium current RG-2 patch-clamp DOI: 10.1067/mtc.2003.85 被引量: 2 ...