Class I antiarrhythmics and sotalol may reduce the risk of death in patients who develop atrial fibrillation
Pentisomide (CM 7857): A New Class I Antiarrhythmic AgentAntiarrhythmic effectCM7857PentisomidePharmacokineticsPharmacologyToxicologydoi:10.1111/j.1527-3466.1993.tb00268.xShiwen YuanS. Bertil OlssonCardiovascular Drug Reviews
80Citations Metrics Abstract Cardiac sodium channels are established therapeutic targets for the management of inherited and acquired arrhythmias by class I anti-arrhythmic drugs (AADs). These drugs share a common target receptor bearing two highly conserved aromatic side chains, and are subdivided by...
M. Classifying antiarrhythmic actions: by facts or speculation. J. Clin. Pharmacol. 32, 964–977 (1992). 9. Milne, J. R. et al. Class 1 antiarrhythmic drugs—characteristic electrocardiographic differences when assessed by atrial and ventricular pacing. Eur. Heart J. 5, 99–107 (1984). ...
AntiarrhythmicclassIXenopusoocyteNa+channelThe effects of bisaramil, a novel diazabicyclononane antiarrhythmic agent, were compared to those of lidocaine, a clinically used class Ib antiarrhythmic agent, on heart, skeletal muscle and brain Na+ channels expressed in Xenopus laevis oocytes using a two...
Class I antiarrhythmic drugs target cardiac two-pore-domain K+ (K2P) background channels作者:Schmidt C; Wiedmann F; Schweizer P A; Katus H A; Thomas D来源:Congress of the European-Society-of-Cardiology (ESC), 2014-08-30 to 2014-09-03....
L-691,121 is a class III antiarrhythmic agent which blocks potassium currents, leading to prolongation of cardiac potential and prevention of cardiac arrhythmia. In a developmental toxicity study in rats, there was a dose-dependent decrease in embryonic/fetal survival, and death of the entire ...
2) Class Ⅲ antiarrhythmic drug Ⅲ类抗心律失常药 1. Dofetilide , a new class Ⅲ antiarrhythmic drug , takes effect through blocking I_(kr) and prolonging action potential duration (QT interval). 多非力特是一种新型Ⅲ类抗心律失常药物,通过抑制钾电流(Ikr)增加动作电位持续时间(QT间期)而发挥...
John A. Tilelli MD, in Pediatric Emergency Medicine, 2008 Class III Drugs: Sotalol and Amiodarone Amiodarone and sotalol, class III antiarrhythmic drugs, are being used with increasing frequency in the pediatric setting. Amiodarone, in particular, has become more prominent in the management of arrhy...
To test whether fatal deterioration of defibrillation efficiency during antiarrhythmic therapy can be prevented by avoiding extreme decrease in ventricular prevented by avoiding extreme decrease in ventricular conduction or toxic plasma drug levels, we determined the defibrillation threshold (DFT) before and ...