Three Class I antiarrhythmic drugs (class IA: quinidine, IB: mexiletine, and IC: flecainide) were tested. After they had been intrathecally injected in rats, the potencies and durations of these drugs on spinal anesthesia were recorded. Bupivacaine, a commonly used local anesthetic, and 5% ...
Campbell.Differing electrophysiological effects of class IA,IB and IC antiarrhythmic drugs on guinea-pig sinoatrial node.British Journal of Pharmacology. 1987Campbell TJ (1987) Differing electrophysiological effects of Class IA, IB and IC an-tiarrhythmic drugs on guinea-pig sinoatrial node Br J ...
A retrospective analysis of 44 patients was carried out to evaluate the efficacy of class IA antiarrhythmic drugs (and/or ), and of drugs of one or more other classes by means of 24-hour Holter recording. This study included only patients who exhibited 5000 or more ventricular premature comple...
This classification divides drug actions into class I for sodium-channel blockade (with subclasses IA, IB and IC), class II for adrenergic antagonism, class III for action-potential prolongation, and class IV for calcium-channel blockade. The development of class I drugs was curtailed when ...
6.33.5.2.1.1 Class 1 antiarrhythmic drugs are all sodium channel blockers All Class 1 drugs block cardiac sodium channels. However, on the basis of the frequency-dependent nature of the block, and the presence or absence of concomitant potassium channel blocking actions resulting in action potentia...
Khodorov BI, Zaborovskaya LD (1986) Use-dependent blockade of sodium channels by local anaesthetics and antiarrhythmic drugs. Effects of chloramine-T and calcium ions. Drugs Exp Clin Res 12:743–752 Kiesecker C, Zitron E, Lück S et al (2004) Class Ia anti-arrhythmic drug ajmaline blocks...
Antiarrhythmicdrugs are most often categorized into 4 classes based on the Vaughan Williams classification system, which is based on the channel or receptor upon which the antiarrhythmic drug acts (Fig. 8.1).68Class I drugs inhibit the influx of sodium into the cell by blocking the sodium (Na+...
a major type of arrhythmia for which antiarrhythmic drugs have a predominant clinical application. Since the 1990s, class IA agents, such as quinidine, have not been the first choice for the treatment of atrial fibrillation because of increased mortal- ity[24]. Such agents have since been ...
CLASS IA AND CLASS IB ANTIARRHYTHMIC DRUGS — A Review of Their Pharmacokinetics, Electrophysiology, Efficacy, and Toxicity Class 1A agents share the electrophysiologic property of slmuing of V max of phase 0 of the action potential and moderate prolongation of the action poten... DM Salerno -...
Quinidine, procainamide and disopyramide are antiarrhythmic drugs in the class 1A category. These drugs have a low toxic to therapeutic ratio, and their use is associated with a number of serious adverse effects during long term therapy and life-threatening sequelae following acute overdose. ...