antiarrhythmic drugssodium channelpotassium effectselectrophysiologic propertiestoxicitySummary This chapter contains section titled: Class IA Procainamide Disopyramide Class IB Class IC ReferenceRichard N. Fogoros M.DPittsburgh, PABlackwell Publishing Ltd...
Summary Quinidine, procainamide and disopyramide are antiarrhythmic drugs in the class 1A category. These drugs have a low toxic to therapeutic ratio, and their use is associated with a number of serious adverse effects during long term therapy and life-threatening sequelae following acute overdose. ...
M. Classifying antiarrhythmic actions: by facts or speculation. J. Clin. Pharmacol. 32, 964–977 (1992). 9. Milne, J. R. et al. Class 1 antiarrhythmic drugs—characteristic electrocardiographic differences when assessed by atrial and ventricular pacing. Eur. Heart J. 5, 99–107 (1984). ...
(AADs). These drugs share a common target receptor bearing two highly conserved aromatic side chains, and are subdivided by the Vaughan-Williams classification system into classes Ia-c based on their distinct effects on the electrocardiogram. How can these drugs elicit distinct effects on the ...
Class III Antiarrhythmic Drugs: Potassium Channel Blockers Implications Owing to their potent cardiac electrophysiologic properties, class III drugs not only exhibit important antiarrhythmic actions but also have the potential to induce life-threatening proarrhythmias, typically TDP. Therefore, anesthesiologists...
Class IA antiarrhythmicwatch out for Daily weight gain of 2 pounds. pyridostigmine -Anticholinesterse - increases ACh-Increases muscle strength -Used in myasthenia gravis (long acting)-Does not penetrate CNSreport muscle weakness or bradycardia.medication is not a cure, but it does relieve symptoms...
Class III Drugs: Sotalol and Amiodarone Amiodarone and sotalol, class III antiarrhythmic drugs, are being used with increasing frequency in the pediatric setting. Amiodarone, in particular, has become more prominent in the management of arrhythmias refractory to other agents. All class III agents prol...
A classification of these drugs has been presented by Vaughan Williams [Vaughan Williams, E. M. J. Clin. Pharmacol., 1984, 24, 129] which is based on their electrophysiological effects on cardiac tissue. Class I agents and subclasses (Ia, Ib, Ic) are defined as antiarrhythmic agents ...
The combination of two different kinds of class I antiarrhythmic agents (class Ia, Ib, or Ic) was examined with regard to their effects on the maximum rate... PS Strain,M Hoyson,B Jamieson - 《Cardiovascular Drugs & Therapy》 被引量: 100发表: 1985年 Expression of human leukocyte antigen...
Class III antiarrhythmic agents are characterized by their ability to prol贸ong action potential and increase refractoriness. The use of these drugs, namely, sotalol hydrochloride and amiodarone hydrochloride, is rising. Both agents are effective for treating a range of ventricular arrhythmias, and ...