The routine use of class IA antiarrhythmic agents to prevent recurrent atrial fibrillation should be abandonedV.J. PlumbELSEVIERAcc Current Journal Review
Figure 6. Examples of class 1c antiarrhythmics. • Toxicity: The toxicity of class 1c drugs includes arrhythmias and cardiovascular depression. 6.33.5.2.1.2 Class 2: b-adrenoceptor blockers: propranolol, atenolol, metoprolol, and many others • Mechanism: There are many β-adrenoceptor blocker...
Class III antiarrhythmic agents are characterized by their ability to prol贸ong action potential and increase refractoriness. The use of these drugs, namely, sotalol hydrochloride and amiodarone hydrochloride, is rising. Both agents are effective for treating a range of ventricular arrhythmias, and ...
This invention relates to thieno tetrahydropyridine and isoquinoline derivative compounds which are useful as antiarrhythmic agents, pharmaceutical compositions comprising such compounds, novel interm
The combination therapy of rapid atrial pacing and the class Ia antiarrhythmic drug is thought to be useful in the therapy of common AF. 展开 关键词: Common type of atrial flutter Class Ia antiarrhythmic drug Pacing therapy Transient entrainment ...
Dhein S, Müller A, Gerwin R, Klaus W (1993) Comparative study on the proarrhythmic effects of some antiarrhythmic agents. Circulation 87:617–630 CrossRef Ehrlich JR, Biliczki P, Hohnloser SH, Nattel S (2008) Atrial-selective approaches for the treatment of atrial fibrillation. J Am Co...
A retrospective analysis of 44 patients was carried out to evaluate the efficacy of class IA antiarrhythmic drugs (and/or ), and of drugs of one or more other classes by means of 24-hour Holter recording. This study included only patients who exhibited 5000 or more ventricular premature comple...
a major type of arrhythmia for which antiarrhythmic drugs have a predominant clinical application. Since the 1990s, class IA agents, such as quinidine, have not been the first choice for the treatment of atrial fibrillation because of increased mortal- ity[24]. Such agents have since been ...
Antiarrhythmic agents and torsades de pointes Sojin YounWass,Mina K.Chung, inTorsades de Pointes, 2022 Classes of antiarrhythmic drugs Antiarrhythmicdrugs are most often categorized into 4 classes based on the Vaughan Williams classification system, which is based on the channel or receptor upon which...
1) class Ⅲ antiarrhythmic agent Ⅲ类抗心律失常药 1. Aim To seekclass Ⅲ antiarrhythmic agents with combinational inhibiting effect on potassium channel and β-receptor. 结论化合物1d、1e、1i、1j表现出Ⅲ类抗心律失常药物延长动作电位时程的特征,有关Ⅲ/Ⅱ复合作用的药理实验有待进行。