Class IA Antiarrhythmics: Quinidine, Procainamide, and DisopyramideKRISTINE A. NAAGAS MDR. BRENT FURBEE MDHaddad and Winchester's Clinical Management of Poisoning and Drug Overdose (Fourth Edition)
Severe intoxication with the class 1A agents may result from acute accidental or intentional overdose, or from accumulation of the drugs during long term therapy. Acute overdose can result in severe disturbances of cardiac conduction and hypotension, frequently accompanied by central nervous system toxici...
The classes include (1) sodium channel blockers, (2) β-adrenoceptor blockers, (3) potassium channel blockers, (4) calcium channel blockers, and (5) selective bradycardic drugs. 6.33.5.2.1.1 Class 1 antiarrhythmic drugs are all sodium channel blockers All Class 1 drugs block cardiac ...
A retrospective analysis of 44 patients was carried out to evaluate the efficacy of class IA antiarrhythmic drugs (and/or ), and of drugs of one or more other classes by means of 24-hour Holter recording. This study included only patients who exhibited 5000 or more ventricular premature comple...
1. Standard microelectrode techniques were used to study the effects on the action potential duration (APD) of canine Purkinje fibres of a therapeutic concentration of nine Class I antiarrhythmic drugs. At an extracellular K+ concentration of 5.6 mmol/L all nine agents reduced APD at all drive ...
Myocardial contractility was studied in vitro in response to treatment with class III antiarrhythmic drug Nibentan. The contractile response to Nibentan in increasing concentrations of 1.66, 2.5, and 3.5 mM was estimated on strips of animal myocardium and human right atrial auricle....
Class IA drugsClass 1A agents share the electrophysiologic property of slmuing of V max of phase 0 of the action potential and moderate prolongation of the action potential duration and refractoriness. Their electrocardiographic effect in therapeutic doses is to prolong the QT c . interval due ...
DURATION OF CLASS IA , B AND C ANTIARRHYTHMIC DRUGS : MODULATION BY STIMULATION RATECampbell, Terence JWyse, Kenneth RPallandi, Regan
Khalighi K, Peters RW, Feliciano Z, et al. Comparison of class Ia/Ib versus Class III antiarrhythmic drugs for the suppression of inducible sustained ventricular tachycardia associated with coronary artery disease. Am J Cardiol 1997; 80: 591–4...
Iost N,Virag L,Varro A,Papp JG.Comparison of the effect of class IA antiarrhythmic drugs on transmembrane potassium currents in rabbit ventricular myocytes. Journal of Cardiovascular Pharmacology . 2003Iost N, Virag L, Varro A, Papp JG. Comparison of the effect of class IA antiarrhythmic drugs ...