Class I antiarrhythmic agents or Na+ channel blockers are among the first drugs that have been used for several decades, and are divided into three groups, according to their cellular electrophysiologic effects. The sodium ion currents or INa enter the cell very fast during phase-0 of action ...
6) class Ⅲ antiarrhythmic agent Ⅲ类抗心律失常药 1. Aim To seekclass Ⅲ antiarrhythmic agents with combinational inhibiting effect on potassium channel and β-receptor. 结论化合物1d、1e、1i、1j表现出Ⅲ类抗心律失常药物延长动作电位时程的特征,有关Ⅲ/Ⅱ复合作用的药理实验有待进行。
Hemmermeister KE, Boerth RC, Warbasse JR. The comparative inotropic effects of six clinically used antiarrhythmic agents. American Heart Journal 84: 643–652, 1972 Google Scholar Henningsen NC, Cederberg A, Hanson A, Johansson BW. Effects of long-term treatment with procaine amide: a prospective ...
6.33.5.2.1.1 Class 1 antiarrhythmic drugs are all sodium channel blockers All Class 1 drugs block cardiac sodium channels. However, on the basis of the frequency-dependent nature of the block, and the presence or absence of concomitant potassium channel blocking actions resulting in action potentia...
To test whether fatal deterioration of defibrillation efficiency during antiarrhythmic therapy can be prevented by avoiding extreme decrease in ventricular prevented by avoiding extreme decrease in ventricular conduction or toxic plasma drug levels, we determined the defibrillation threshold (DFT) before and ...
AntiarrhythmicclassIXenopusoocyteNa+channelThe effects of bisaramil, a novel diazabicyclononane antiarrhythmic agent, were compared to those of lidocaine, a clinically used class Ib antiarrhythmic agent, on heart, skeletal muscle and brain Na+ channels expressed in Xenopus laevis oocytes using a two...
Class I and IV antiarrhythmic drugs and cytosolic calcium regulate mRNA encoding the sodium channel α-subunit in rat cardiac muscle. Mol Pharmacol 1992;42:570-574.Duff HJ, Offord J, West J, Catterall WA. Class I and IV antiarrhythmic drugs and cytosolic calcium regulate mRNA encoding the ...
1) class Ⅲ antiarrhythmic agent Ⅲ类抗心律失常药 1. Aim To seekclass Ⅲ antiarrhythmic agents with combinational inhibiting effect on potassium channel and β-receptor. 结论化合物1d、1e、1i、1j表现出Ⅲ类抗心律失常药物延长动作电位时程的特征,有关Ⅲ/Ⅱ复合作用的药理实验有待进行。
Although cardiac sodium channel blocking drugs can exert antiarrhythmic actions, they can also provoke life-threatening arrhythmias through a variety of me... VUM Departmentofmedicine,VUM Departmentofpharmacology - 《Cardiac Electrophysiology Clinics》 被引量: 0发表: 2014年 The role of late I and ant...
Although cardiac sodium channel blocking drugs can exert antiarrhythmic actions, they can also provoke life-threatening arrhythmias through a variety of me... VUM Departmentofmedicine,VUM Departmentofpharmacology - 《Cardiac Electrophysiology Clinics》 被引量: 0发表: 2014年 The role of late I and ant...