Figure 6. Examples of class 1c antiarrhythmics. • Toxicity: The toxicity of class 1c drugs includes arrhythmias and cardiovascular depression. 6.33.5.2.1.2 Class 2: b-adrenoceptor blockers: propranolol, atenolol, metoprolol, and many others • Mechanism: There are many β-adrenoceptor blocker...
class 1c antiarrhythmic agentcoronary arteryflecainidevoltage‐dependent K + channelsSummary This study examined the inhibitory effect of flecainide, a class 1c antiarrhythmic agent (Na + channel blocker), on voltage‐dependent K + (Kv) channels in smooth muscle cells isolated from coronary arteries....
Ro 22-9194Thromboxane A 2 synthaseCommercially available serotonin-type 3 (5-HT3) receptor antagonists (ondansetron, granisetron, and tropisetron) have shown no clinically significant adverse effects on the cardiovascular system. In the dose-ranging evaluation of dolasetron, computer-generated ECGs ...
Pentisomide (CM 7857): A New Class I Antiarrhythmic AgentAntiarrhythmic effectCM7857PentisomidePharmacokineticsPharmacologyToxicologydoi:10.1111/j.1527-3466.1993.tb00268.xShiwen YuanS. Bertil OlssonCardiovascular Drug Reviews
Furthermore, a Class I agent with an optimal electrophysiologic profile still computes to be a two-edged sword, possessing both antiarrhythmic and proarrhythmic properties. Fortunately, it is possible to conceive of drug profiles that would be purer antiarrhythmic agents. For example, a drug that...
Ibutilide is the first class III antiarrhythmic agent to rely on activation of a slow inward sodium current to prolong the action potential and effective refractory period of atrial and ventricular tissue. The drug is indicated for the rapid restoration of normal sinus rhythm in patients with ...
1) class Ⅲ antiarrhythmic agent Ⅲ类抗心律失常药 1. Aim To seekclass Ⅲ antiarrhythmic agents with combinational inhibiting effect on potassium channel and β-receptor. 结论化合物1d、1e、1i、1j表现出Ⅲ类抗心律失常药物延长动作电位时程的特征,有关Ⅲ/Ⅱ复合作用的药理实验有待进行。
The effects of bepridil, a new Ca channel blocking agent with reported antiarrhythmic action, were examined in single isolated ventricular cells using whole-cell patch clamp techniques. Ca currents were studied in guinea-pig ventricular ... A Yatani,AM Brown,A Schwartz - 《Journal of Pharmacology...
6) class Ⅲ antiarrhythmic agent Ⅲ类抗心律失常药 1. Aim To seek class Ⅲ antiarrhythmic agents with combinational inhibiting effect on potassium channel and β-receptor. 结论化合物1d、1e、1i、1j表现出Ⅲ类抗心律失常药物延长动作电位时程的特征,有关Ⅲ/Ⅱ复合作用的药理实验有待进行。 更多例句>...
A sensitive and specific method based on radioimmunoassay (RIA) has been developed for the analysis of L-691,121, a new antiarrhythmic agent, and its major metabolite, L-692,199, in plasma. Two RIAs using immunogens and radioligands prepared from different derivatives of L-691,121 were used...