Reduced expression of voltage-gated sodium channels in neurons cultured from trisomy 16 mouse hippocampus. Int J Dev Neurosci. 1996; 14:749-760. [PubMed: 8960982]STOLL J AND GALDZICKI Z. Reduced expression of voltage-gated sodium channels in neurons cultured from trisomy 16 mouse hippocampus. ...
voltage-gated sodium channelVoltage-gated sodium channels (VGSCs) are the basic ion channels for neuronal excitability, which are crucial for the resting potential and the generation and propagation of action potentials in neurons. To date, at least nine distinct sodium channel isoforms have been ...
sodium channel pharmacologyPage 59. —CHAPTER 3 Voltage-Gated Sodium Channels in Peripheral Nociceptive Neuronsas Targets for the Treatment of Pain THEODORE R. CUMMINS Department of Pharmacologyand Toxicology, Stark Neurosciences Research Institute, Indiana University School of...
In the nervous system, calcium channel blockers have been used successfully to treat absence seizures, and are emerging as potential therapeutic avenues for pathologies such as pain, Parkinson disease, addiction and anxiety. This Review provides an overview of calcium channels as drug targets for ...
The spiral ganglion neurons (SGN) provide the afferent innervation of the hair cells in the organ of Corti and relay auditory information from the inner ear to the brain. Voltage-gated sodium channels (Na V) initiate and propagate action potentials that encode this sensory information but little...
网络释义 1. 电压门控钠离子通道 电压门控钠离子通道(voltage-gated sodium channels)是可兴奋细胞产生电兴奋的基础结构,其α亚单位为基本功能单位,可… www.ebiotrade.com|基于 1 个网页 2. 电压门控钠通道 电压门控通道,voltage gated... ... )voltage-gated sodium channels电压门控钠通道) voltage gated...
Voltage-gated ion channels are membrane proteins which underlie rapid electrical signals among neurons and the spread of excitation in skeletal muscle and heart. We outline some recent advances in the study of voltage-sensitive sodium and calcium channels. Investigations are providing insight into the ...
Voltage-gated sodium channels shape subthreshold EPSPs in layer 5 pyramidal neurons from rat prefrontal cortex. 来自 Semantic Scholar 喜欢 0 阅读量: 40 作者: González-Burgos, Guillermo,G Barrionuevo 摘要: The role of voltage-dependent channels in shaping subthreshold excitatory postsynaptic potentials...
Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate classic action potentials, showing potential as a pr...
In addition to decreasing transient sodium currents in Purkinje neurons, CaMKII inhibition with tatCN21 also reduces persistent current density (Fig. 1D). Current densities were calculated by normalizing the current amplitude at −25 mV by the cell capacitance. We used −25 mV for transient ...