Voltage-gated sodium channels and their roles in drug action. Curr Anaesth Crit Care 2005;16: 81-7.Errington AC,Madison K,Kumar A. Voltage-gated sodium channels and their roles in drug action[J].Curr Anaesth Crit Care,2005,(02):81-87.doi:10.1016/j.cacc.2005.03.001....
Voltage-gated Sodium Channels: Structure and FunctionSodium Channel Blockers in Clinical Use BenzocaineBupivacaineEtidocaineLevobupivacaineLidocaine (Lignocaine)MepivacainePrilocaineProcaineRopivacaineTetracaineAnticonvulsant Drugs CarbamazepineLamotrigineOxcarbazepinePhenytoinAntiarrhythmic Drugs MexilitineSodium channel ...
A. Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol. Rev. 57, 387–395 (2005). Article CAS PubMed Google Scholar Catterall, W. A. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26, ...
In this review we will endeavour to explain the physiological roles of voltage-gated sodium channels, their molecular classification, structure and modulation by drugs. 展开 关键词: Anti-convulsant Muscle relaxant (suxamethonium) Mood stabilizers Neuropathic pain Electrophysiology Ion channel superfamilies ...
Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most ...
Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate clas
Faculty of 1000 evaluation for Voltage-Gated Ion Channels in the PNS: Novel Therapies for Neuropathic Pain? R Eckenhoff 被引量: 0发表: 2018年 Voltage-Gated Sodium Channels: Therapeutic Targets for Pain Objective. To provide an overview of the role of voltage-gated sodium channels in ...
M. H. Alshukri1, Munawar S. Ahmad1,3, Erich Y. T. Nakasu1, Mohammed H. Awwad4, Elham M. Salama2, Angharad M. R. Gatehouse1 & Martin G. Edwards1 The voltage-gated sodium ion channel (VGSC) belongs to the largest superfamily of ion channels....
Voltage-gated sodium channel toxins 喜欢 0 阅读量: 21 作者:Kenneth,M.,BlumenthalAnna,L.,Seibert 摘要: Neurotoxins have served as invaluable agents for identification, purification, and functional characterization of voltage-gated ion channels. Multiple classes of these toxins, which target voltage-...
voltage-gated sodium channel inhibitors such as 4-[(3S,3'R)-3-(3,5-dichlorophenyl)-2'-oxo-1,3'-bipyrrolidin-1'-yl)]-N-(thiazol-2-yl)benzenesulfonamide, used for the treatment of neuropathic or inflammatory pain, arthritis, headaches, neuralgia, epilepsy, neurodegenerative or psychiatric ...