voltage-gated ion channelsvoltage-gated sodium channelsvoltage-gated potassium channelschloride channelsKCNQ channelsubiquitin ligaseThe electrical excitability of neurons is mediated primarily by voltage-gated ion channels, particularly voltage-gated Na+ (Nav), K+ (Kv) and Cl- (ClC) channels. Cells ...
A. Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol. Rev. 57, 387–395 (2005). Article CAS PubMed Google Scholar Catterall, W. A. From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron 26, ...
The actions on these targets can be categorized into five broad groups: (a) modulation of voltage-gated ion channels, including sodium, calcium, and potassium channels; (b) enhancement of γ-aminobutyric acid (GABA) inhibition through effects on GABAA receptors, the GAT-1 GABA transporter or ...
网络释义 1. 电压门控钠离子通道 电压门控钠离子通道(voltage-gated sodium channels)是可兴奋细胞产生电兴奋的基础结构,其α亚单位为基本功能单位,可… www.ebiotrade.com|基于 1 个网页 2. 电压门控钠通道 电压门控通道,voltage gated... ... )voltage-gated sodium channels电压门控钠通道) voltage gated...
Voltage-gated Sodium Channels: Structure and FunctionSodium Channel Blockers in Clinical Use BenzocaineBupivacaineEtidocaineLevobupivacaineLidocaine (Lignocaine)MepivacainePrilocaineProcaineRopivacaineTetracaineAnticonvulsant Drugs CarbamazepineLamotrigineOxcarbazepinePhenytoinAntiarrhythmic Drugs MexilitineSodium channel ...
Excitable cells — including neurons, muscle cells and cardiac myocytes — are unique in expressing high densities of voltage-gated sodium (NaV) channels. This molecular adaptation enables these cells to produce action potentials, and is essential to their function. With the advent of the molecular...
In this review we will endeavour to explain the physiological roles of voltage-gated sodium channels, their molecular classification, structure and modulation by drugs. 展开 关键词: Anti-convulsant Muscle relaxant (suxamethonium) Mood stabilizers Neuropathic pain Electrophysiology Ion channel superfamilies ...
Solubility: Soluble to 100 mM in ethanol and to 100 mM in DMSO Purity: ≥99% Storage: Store at RT CAS No: 137-58-6 The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. ...
Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most ...
Electrical signaling by ion channels is a fundamental cellular regulatory pathway in all organisms from prokaryotes to humans. Voltage-gated Na+ (VGSC), Ca2+ (VGCC), and K+ (VGPC) channels are responsible for action potential generation in electrically e