J. Bolanowski, "Voltage-gated sodium channels are present on both the neural and capsular structures of Pacinian corpuscles," Somatosens. Mot. Res., vol. 19, no. 3, pp. 231-237, 2002.L. Pawson and S. J. Bolanowski, "Voltagegated sodium chan nels are...
网络释义 1. 电压门控钠离子通道 电压门控钠离子通道(voltage-gated sodium channels)是可兴奋细胞产生电兴奋的基础结构,其α亚单位为基本功能单位,可… www.ebiotrade.com|基于 1 个网页 2. 电压门控钠通道 电压门控通道,voltage gated... ... )voltage-gated sodium channels电压门控钠通道) voltage gated...
Voltage-gated sodium channels are expressed across excitable cells where they are crucial for sharp initiation dynamics and propagation of the action potential1. TheSCN5Agene encodes for the cardiac sodium channel α-subunit, Nav1.5.SCN5Amutations have been linked to cardiac arrhythmias such as Brugad...
Local anesthetics which preferentially interact with voltage-gated sodium channels (VGSCs) were shown to have a clinical beneficial effect in ulcerative colitis and to regulate the secretion of inflammatory mediators from intestinal epithelial cells. However, expression of VGSCs in epithelial cells was ...
Voltage-gated sodium channels are dynamic membrane proteins characterized by rapid conformational changes that switch the molecule between closed resting, ... Cronin,B N. - 《Journal of Biological Chemistry》 被引量: 95发表: 2003年 Abnormal expression of voltage-gated sodium channels Nav1.7, Nav1.3...
Rationale: Voltage-gated sodium channels initiate action potentials in excitable tissues. Mice in which Scn5A (the predominant sodium channel gene in heart) has been knocked out die early in development with cardiac malformations by mechanisms which have yet to be determined.Objective: Here we addres...
β Subunits of Voltage-gated Sodium Channels Are Novel Substrates of β-Site Amyloid Precursor Protein-cleaving Enzyme (BACE1) and γ-Secretase Sequential processing of amyloid precursor protein (APP) by membrane-bound proteases, BACE1 and 纬-secretase, plays a crucial role in the pathogenesis of ...
Voltage-gated sodium channels are protein complexes comprised of one pore forming α subunit and two, non-pore forming, β subunits. The voltage-gated sodium channel β subunits were originally identified to function as auxiliary subunits, which modulate the gating, kinetics, and localization of the...
Voltage-gated sodium channels are encoded by a family of ten structurally-related genes that are expressed in spatially and temporally distinct patterns, mainly in excitable tissues. They underlie electrical signalling in nerve and muscle. It has long been known that sodium channel blockers are anaes...
Voltage-gated sodium channels (VGSCs) initiate action potentials in electrically excitable cells and tissues. Surprisingly, some VGSC genes are aberrantly expressed in a variety of cancers, derived from “non-excitable” tissues that do not generate clas