Ion Channel GatingMolecular StructureProtein ConformationThe voltage-sensitive ion channels are responsible for generation of conducted action potentials in excitable cells and for a wide range of regulatory events in nonexcitable cells. On depolarization, permeability to sodium, calcium, or potassium ...
Structure and function of voltage‐gated sodium channels 1 Sodium channels mediate fast depolarization and conduct electrical impulses throughout nerve, muscle and heart. This paper reviews the links between sodium channel structure and function. 2 Sodium channels have a modular architecture, ... E Ma...
Voltage-gated Sodium Channels: Structure and FunctionSodium Channel Blockers in Clinical Use BenzocaineBupivacaineEtidocaineLevobupivacaineLidocaine (Lignocaine)MepivacainePrilocaineProcaineRopivacaineTetracaineAnticonvulsant Drugs CarbamazepineLamotrigineOxcarbazepinePhenytoinAntiarrhythmic Drugs MexilitineSodium channel ...
Voltage-gated sodium channels (VGSC).AAn example structure of the VGSC α-subunit/β-subunit protein complex.BCartoon illustration of VGSC α-subunit and β-subunit proteins within the membrane.CTopology diagram of VGSC α-subunit and β-subunit proteins.DProtein and gene names of VGSC molecules....
Fast opening and closing of voltage-gated sodium channels are crucial for proper propagation of the action potential through excitable tissues. Unlike potassium channels, sodium channel α-subunits are believed to form functional monomers. Yet, an increa
This opens new avenues to understand the biophysics of gating and the channels' structure function dynamics, thereby potentially paving the way for new drugs with fewer side effects. This chapter highlights the physiological relevance of voltage-gated sodium channels within their complex cellular ...
Voltage-gated sodium (NaV) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs and disease mutations, but the structural basis for their voltage-dependent activation, ion selectivity and drug block is unknow
Structure and function of voltage-gated sodium channels at atomic resolution New Findings What is the topic of this review?The central goal of the research reviewed here is to understand the functional properties of voltage-gated so... Catterall,A William - 《Experimental Physiology》 被引量: ...
Voltage-dependent movement of a sodium channel S4 segment was examined by cysteine scanning mutagenesis and testing accessibility of the residues to hydrop... N Yang,AL George,R Horn - 《Neuron》 被引量: 1115发表: 1996年 Voltage-gated sodium channels at 60: structure, function and pathophysiolo...
Forty Years of Sodium Channels: Structure, Function, Pharmacology, and Epilepsy Article 07 June 2017 The conformational cycle of a prototypical voltage-gated sodium channel Article 16 November 2020 The complete structure of an activated open sodium channel Article Open access 16 February 2017 ...