Voltage-gated sodium channels (VGSC).AAn example structure of the VGSC α-subunit/β-subunit protein complex.BCartoon illustration of VGSC α-subunit and β-subunit proteins within the membrane.CTopology diagram of VGSC α-subunit and β-subunit proteins.DProtein and gene names of VGSC molecules....
Voltage-gated sodium (NaV) channels initiate electrical signalling in excitable cells and are the molecular targets for drugs and disease mutations, but the structural basis for their voltage-dependent activation, ion selectivity and drug block is unknow
Figure 4. Diagram of the voltage-gated calcium channel. The α1 subunit of the channel is comparable to the α subunit of the voltage-gated sodium channel and consists of four homologous domains labeled I-IV, each containing six transmembrane spanning segments termed S1–S6 and a P region. ...
Sodium channelToxinVoltage-gated ion channels are the target of a range of naturally occurring toxins and therapeutic drugs. There is a great interest in better understanding how these diverse compounds alter channel function in order to design the next generation of therapeutics that can selectively ...
Voltage-gated sodium channel alpha-subunits have been shown to be key mediators of the pathophysiology of pain. The present review considers the role of so... LL Isom - 《Am J Physiol Gastrointest Liver Physiol》 被引量: 53发表: 2000年 Voltage-gated calcium channels and their auxiliary subuni...
Voltage-gated sodium channel Nav 1.5 contributes to astrogliosis in an in vitro model of glial injury via reverse Na+ /Ca2+ exchange. Voltage-gated sodium channel Nav 1.5 contributes to astrogliosis in an in vitro model of glial injury via reverse Na+ /Ca2+ exchange. Glia. 2014;62:... ...
,LIN, Guoliang,NIE, Hong 国省代号: WO 被引量: 19 摘要: The present invention relates to voltage-gated sodium channel blocker intermediates, compounds and dimers, corresponding pharmaceutical compositions, compound preparation and treatment methods for respiratory or respiratory tract diseases....
De novo mutations of voltage-gated sodium channel alphaII gene SCN2A in intractable epilepsies. BACKGROUND: Mutations of voltage-gated sodium channel alpha(II) gene, SCN2A, have been described in a wide spectrum of epilepsies. While inherited SCN2A mu... I Ogiwara,K Ito,Y Sawaishi,... -...
Voltage-gated sodium channels are encoded by a family of ten structurally-related genes that are expressed in spatially and temporally distinct patterns, mainly in excitable tissues. They underlie electrical signalling in nerve and muscle. It has long been known that sodium channel blockers are anaes...
NaVs are found in metazoans from jellyfish to humans and are formed by large polytopic transmembrane proteins that are members voltage-gated ion channel (VGIC) signaling protein superfamily [1], [2]. This class encompasses voltage-gated channels for sodium, calcium, and potassium; the large fami...