Voltage-gated sodium channels are vital membrane proteins essential for electrical signalling; in humans, they are key targets for the development of pharmaceutical drugs. Here we report the crystal structure of an open-channel conformation of NavMs, the bacterial channel pore from the marine ...
Hyperpolarization and cyclic nucleotide (HCN) activated ion channels are critical for the automaticity of action potentials in pacemaking and rhythmic electrical circuits in the human body. Unlike most voltage-gated ion channels, the HCN and related plant ion channels activate upon membrane hyperpolarizat...
Ionotropic glutamate receptors (iGluRs) are tetrameric ligand-gated ion channels that open their pores in response to binding of the agonist glutamate1,2,3. An ionic current through a single iGluR channel shows up to four discrete conductance levels (O1–O4)4,5,6. Higher conductance levels h...
Voltage-gated sodium channels activate in response to depolarization, but it is unknown whether the voltage-sensing arginines in their S4 segments pivot ac... S Sokolov,T Scheuer,WA Catterall - 《Neuron》 被引量: 193发表: 2005年 Anandamide inhibits nuclear factor-kappaB activation through a can...
Inhibition of the Voltage-Gated Sodium Current and Opening of Nanopores By Ultra -Short Electric Pulsespregnancypre-eclampsiahypertensionblood pressure variabilitysegmented Poincare plot analysiscardiovascular regulationNot Availabledoi:10.1016/j.bpj.2009.12.3277Nesin, Vasyl...
A family of ATP-gated, non-selective cation channels known as P2X receptors are involved in purinergic synaptic transmission and other, as yet poorly defined, functions. After repeated exposure to ATP some of these channels no longer respond, a phenomenon known as run-down. In some P2X ...
At dawn, the blue light (BL)-activated PM proton (H+) pump H+-ATPase transports H+ from the cytosol to the apoplast, at the expense of hydrolysing ATP, causing hyperpolarisation of the PM and activation of voltage-gated K+ channels6. The resulting influx of K+ ions lowers GC water ...
Suhua Zhang1, Hui Yu1, Mian Long2, Hailin Zhang4, Diomedes E. Logothetis5, Yong Zhan1 & Hailong An1 The gating of Kir channels depends critically on phosphatidylinositol 4,5-bisphosphate (PIP2), but the detailed mechanism by which PIP2 regulates Kir channels remains obsc...
The anion channel TMEM16A is activated by intracellular Ca2+ in a highly cooperative process. By combining electrophysiology and autocorrelation analysis, we investigated the mechanism of channel activation and the concurrent rearrangement of the gate in
A voltage-gated channel, the activation of which leads to the appearance of a transient K+current. It takes its name fromDrosophilawith mutations in the gene that encodes this protein. These flies display a violent shaking phenotype when under anaesthesia. ...