functionnervous systemneurological diseasesvoltage-gated sodium channelVoltage-gated sodium channels (VGSCs) are the basic ion channels for neuronal excitability, which are crucial for the resting potential and the generation and propagation of action potentials in neurons. To date, at least nine ...
Structure and function of voltage‐gated sodium channels 1 Sodium channels mediate fast depolarization and conduct electrical impulses throughout nerve, muscle and heart. This paper reviews the links between sodium channel structure and function. 2 Sodium channels have a modular architecture, ... E Ma...
(2002). Gastric hyperalgesia and changes in voltage gated sodium channel function in the rat. Gut, 51 Suppl 1, i15-i18.Gebhart GF, Bielefeldt K, and Ozaki N. Gastric hyperalgesia and changes in voltage gated sodium channel function in the rat. Gut 51, Suppl 1: I15-I18, 2002....
These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs ...
Voltage-gated sodium channels (VGSCs) are responsible for the fast upstroke of the action potential. Fine-tuned regulation and naturally occurring mutations of VGSCs modify neuronal and muscle function. In this chapter we highlight structure, function and disease relevance of VGSCsbased on recent ...
voltage‐gated ion channelssodium channelsbenzocainebupivacaineetidocainelevobupivacainelidocainemepivacaineprilocaineVoltage-gated Sodium Channels: Structure and FunctionSodium Channel Blockers in Clinical Use BenzocaineBupivacaineEtidocaineLevobupivacaineLidocaine (Lignocaine)MepivacainePrilocaineProcaineRopivacaine...
Recently, structural studies of members of a large family of bacterial voltage-gated sodium channels (BacNaVs) prevalent in soil, marine, and salt lake environments that bear many of the core features of eukaryotic NaVs have reframed ideas for voltage-gated channel function, ion selectivity, and...
Structure and function of voltage-gated sodium channels at atomic resolution New Findings What is the topic of this review?The central goal of the research reviewed here is to understand the functional properties of voltage-gated so... Catterall,A William - 《Experimental Physiology》 被引量: ...
Voltage-gated Na(+) channels (Nav) are essential for myocyte membrane excitability and cardiac function. Nav current (INa) is a large-amplitude, short-duration spike generated by rapid channel activation followed immediately by inactivation. However, even under normal conditions, a small late compone...
aModelação do lago de montante 正在翻译,请等待...[translate] aLoss-of-function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with irritable bowel syndrome 正在翻译,请等待...[translate]