Virtually, voltage-gated sodium (Na+) channels are expressed in all electrically excitable tissues and are essential for muscle contraction, and conduction of impulses within the peripheral as well as central nervous systems. Genetic disorders that disrupt the function of voltage-gated sodium (Na+) ...
NAV1.9 Voltage-Gated Sodium ChannelNeuropathic pain occurs as a result of some form of injury to the nervous system. Although the basis of the disease remains to be fully elucidated, numerous studies have suggested a major role for ion channels in the pathogenesis of neuropathic pain. As Na+ ...
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The hinged-lid model was long accepted as the canonical model for fast inactivation in Nav channels. It predicts that the hydrophobic IFM motif acts intracellularly as the gating particle that binds and occludes the pore during fast inactivation. However
Fast opening and closing of voltage-gated sodium channels are crucial for proper propagation of the action potential through excitable tissues. Unlike potassium channels, sodium channel α-subunits are believed to form functional monomers. Yet, an increa
3.3. NaV1.5 Sodium Channels Are Responsible for the Generation of Macroscopic Na+ Currents in Colon Cancer Cells We then investigated and characterized the activity of NaV channels in colon cancer cell lines by measuring macroscopic Na+ currents using the patch clamp technique in a whole-cell confi...
Gives unprecedented insight into the structural basis of sodium channel function Explores sodium channels from the perspectives of their biophysical behavior Written by leading experts in the field Includes supplementary material: sn.pub/extras Part of the book series: Handbook of Experimental Pharmacology...
Voltage-gated sodium channels and metastatic disease Voltage-gated Na+ channels (VGSCs) are macromolecular protein complexes containing a pore-forming α subunit and smaller non-pore-forming β subunits. VGSC... Brackenbury,J William - 《Channels》 被引量: 145发表: 2012年 Slow inactivation in vo...
Voltage-gated Sodium (NaV) Channels Sodium Channels Autophagy Cell Metabolism 按产品操作查看相关产品 查看全部 Voltage-gated Sodium (NaV) Channel Blockers 关键词: Carbamazepine, Carbamazepine supplier, sodium, Na+, channels, GABAA, ligands, inhibits, inhibitors, anticonvulsants, CBZ, Voltage-gated, Sod...
Our results suggest that Nav1.5 and NCX are potential targets for modulation of astrogliosis after injury via their effect on [Ca2+]i. GLIA 2014;62:1162–1175 展开 关键词: glial scar sodium channels sodium–calcium exchanger migration proliferation DOI: 10.1002/glia.22671 被引量: 7 年份...