In neurons, voltage-gated sodium channels (Na v) are involved in neuropathic pain and are activated by depolarization. Since keratinocytes can also show changes in membrane potential, we used RT-PCR, in situ hybridization, and immunohistochemistry to investigate the expression of sodium channels in ...
Voltage-gated sodium channels (VGSCs) are transmembrane proteins that increase the permeability of sodium ions across membranes. The permeability of these channels depends on the voltage drop across the membrane. In a typical neuronal action potential, VGSCs remain closed until the membrane potential ...
The voltage-dependence of IK activation was fitted with the following Boltzmann equation: y = t / (1 + exp((V50 –E)/k)), where E is the applied voltage, V50 is the voltage at which 50% of the channels are activated, t is the top of the curve, and k is the slope factor. ...
Voltage-gated sodium, calcium, and potassium channels share many similarities and are members of a single superfamily of voltage-gated cation channels [1,7]. The primary pore-forming α subunit of each channel consists of four homologous domains termed I–IV, with each domain containing six trans...
Voltage-gated sodium (Na+) channels (VGSCs) are complex, transmembrane proteins that have a role in governing electrical activity in excitable tissues. The Na+ channel is activated in response to depolarization of the cell membrane that causes a voltage-dependent conformational change in the channel...
4) voltage-activated K+ current 电压门控钾电流 5) voltage-gated sodium channels 电压-门控Na+通道 1. Thevoltage-gated sodium channelshave a close relationship with epilepsy,and many epileptic syndromes are proved to be caused by mutations ofvoltage-gated sodium channels. ...
and Kir4.1 channels. For each of the four encoding genes, we found at least one regulatory region that is activated by Sox10 in vitro and at the same time bound by Sox10 in vivo. Cell-specific deletion of Sox10 in oligodendroglial cells furthermore led to a strong downregulation of all...
This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with ...
Changes in cardiac myocyte morphology alter the properties of voltage-gated ion channels. Objective: The goal of this study was to determine if the properties of the transient outward potassium (Ito), TTX-resistant sodium (INa Walsh,Kenneth,B.,... - 《Cardiovascular Research》 被引量: 55发表...
each of which is analogous to a single domain of the principal subunits of sodium or calcium channels (Figure 1). The voltage-gated potassium channels are remarkable for their diversity. They include 40 different channels that are classified into 12 distinct groups based on their amino...