Nerve cells are electrically excitable because of the presence of voltage-sensitive ion channels in their surface membranes that are selective for Na+, K+, or Ca2+. These channels contribute significantly to signal processing and transmission in neurons. This chapter reviews the physiological ...
neurons - gating charge - sodium channels - caffeineUsing a voltage-clamp technique and intracellular dialysis, gating currents of sodium channels were first recorded and studied in neurons of the rat trigeminal ganglia. The rising phase of gating currents lasted 30 to 70 sec; these currents ...
Polarized distribution of ion channels within microdomains of the axon initial segment. J. Comp. Neurol. 500, 339–352 (2007). PubMed Google Scholar Royeck, M. et al. Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. J. Neurophysiol. 100, ...
Excitable cells — including neurons, muscle cells and cardiac myocytes — are unique in expressing high densities of voltage-gated sodium (NaV) channels. This molecular adaptation enables these cells to produce action potentials, and is essential to their function. With the advent of the molecular...
Sodium channels are important for generating electrical signals in neurons. Latest Research and Reviews Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6 Luis Manuel Arratia Juan David Bermudes-Contreras Absalom Zamorano-Carrillo ResearchOpen ...
Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons This paper provides a brief overview of the diversity of voltage-gated Ca2+ channels and our recent work on neuronal Ca2+ channels with novel pharmacologic... JF Zhang,AD ...
Cloning and functional expression of a new epithelial sodium channel δ subunit isoform differentially expressed in neurons of the human and monkey telence... Epithelial sodium channel (ENaC) is a member of the ENaC/degenerin family of amiloride-sensitive, non-voltage gated sodium ion channels. EN...
Genes encoding sodium channels Nav1.1, Nav1.2, Nav1.3, and Nav1.7 are localized on chromosome 2 in human and mouse, and these channels share similarities in sequence, biophysical characteristics, block by nanomolar concentrations of tetrodotoxin, and broad expression in neurons. A second cluster of...
1.a soft, silver-white, chemically active metallic element that occurs naturally only in combination: a necessary element in the body for the maintenance of normal fluid balance and other physiological functions.Symbol:Na;at. wt.:22.9898;at. no.:11;sp. gr.:0.97 at 20°C. ...
V oltage-gated ion channels play a crucial role in the spread of action potentials by producing electrical signals in neurons and other excitable cells1. Voltage-gated sodium channels (VGSCs) are especially responsible for excitability in neuronal, neuroendocrine, skeletal muscle and cardiac cells. ...