neurons - gating charge - sodium channels - caffeineUsing a voltage-clamp technique and intracellular dialysis, gating currents of sodium channels were first recorded and studied in neurons of the rat trigeminal ganglia. The rising phase of gating currents lasted 30 to 70 sec; these currents ...
Sodium channels can provide a route for a persistent influx of sodium ions into neurons. Over the past decade, it has emerged that sustained sodium influx can, in turn, trigger calcium ion influx, which produces axonal injury in neuroinflammatory disorders such as multiple sclerosis (MS). The ...
Polarized distribution of ion channels within microdomains of the axon initial segment. J. Comp. Neurol. 500, 339–352 (2007). PubMed Google Scholar Royeck, M. et al. Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. J. Neurophysiol. 100, ...
THE inward sodium current underlying the nerve action potential is carried by discrete Na channels1 in the membrane which are gated in response to the membrane potential. A basic question in understanding the gating mechanism is whether the conductance of the channels has only two states, open and...
Excitable cells — including neurons, muscle cells and cardiac myocytes — are unique in expressing high densities of voltage-gated sodium (NaV) channels. This molecular adaptation enables these cells to produce action potentials, and is essential to their function. With the advent of the molecular...
Distinctive pharmacology and kinetics of cloned neuronal Ca2+ channels and their possible counterparts in mammalian CNS neurons This paper provides a brief overview of the diversity of voltage-gated Ca2+ channels and our recent work on neuronal Ca2+ channels with novel pharmacologic... JF Zhang,AD ...
Ion channels are crucial components of cellular excitability and are involved in many neurological diseases. This review focuses on the sodium leak, G protein-coupled receptors (GPCRs)-activated NALCN channel that is predominantly expressed in neurons where it regulates the resting membrane potential an...
Sodium channels are important for generating electrical signals in neurons. Latest Research and Reviews Experimental and computational evidence that Calpain-10 binds to the carboxy terminus of NaV1.2 and NaV1.6 Luis Manuel Arratia Juan David Bermudes-Contreras Absalom Zamorano-Carrillo ResearchOpen ...
1.a soft, silver-white, chemically active metallic element that occurs naturally only in combination: a necessary element in the body for the maintenance of normal fluid balance and other physiological functions.Symbol:Na;at. wt.:22.9898;at. no.:11;sp. gr.:0.97 at 20°C. ...
V oltage-gated ion channels play a crucial role in the spread of action potentials by producing electrical signals in neurons and other excitable cells1. Voltage-gated sodium channels (VGSCs) are especially responsible for excitability in neuronal, neuroendocrine, skeletal muscle and cardiac cells. ...