Neurosciences Non cell autonomous roles of voltage -gated sodium channels in neural development UNIVERSITY OF COLORADO HEALTH SCIENCES CENTER Angeles Ribera WrightMelissa AdrianneVoltage-gated sodium channels are well known for their role in action potential generation and propagation in mature neurons and ...
Voltage-gated calcium channels are important regulators of brain, heart and muscle functions, and their dysfunction can give rise to pathophysiological conditions ranging from cardiovascular disorders to neurological and psychiatric conditions such as epilepsy, pain and autism. In the nervous system, calciu...
Of the limited studies on gain control, some have examined the roles of synaptic noise and passive somatic currents, but the roles of voltage-gated channels present ubiquitously in neurons have been less explored. Here, we systematically examined the relationship between gain and voltage-gated ion ...
Voltage-gated sodium channels (VGSCs) are the basic ion channels for neuronal excitability, which are crucial for the resting potential and the generation and propagation of action potentials in neurons. To date, at least nine distinct sodium channel isoforms have been detected in the nervous ...
Voltage-gated Na+ channels in chemoreceptor afferent neurons—Potential roles and changes with developmentdoi:10.1016/j.resp.2012.08.009... David,F.,Donnelly - 《Respiratory Physiology & Neurobiology》 被引量: 0发表: 2013年 Voltage-gated Na + channels in chemoreceptor afferent neurons—Potential role...
Using the whole-cell patch-clamp technique, Ca2+ channel currents were examined in three distinct types of neurons derived from rat primary visual cortex. ... K Giffin,JS Solomon,A Burkhalter,... - 《Neuron》 被引量: 282发表: 1991年 The role of voltage-gated chloride channels in type II...
Page 59. —CHAPTER 3 Voltage-Gated Sodium Channels in Peripheral Nociceptive Neuronsas Targets for the Treatment of Pain THEODORE R. CUMMINS Department of Pharmacologyand Toxicology, Stark Neurosciences Research Institute, Indiana University School of...
Voltage-gated sodium channels are proteins found in mammalian neurons that are responsible for generating electrical signals known as action potentials. When the membrane of a neuron becomes depolarized, these channels briefly open, allowing sodium ions to enter the cell. Sodium channels are composed ...
Roles of tetrodotoxin (TTX)-sensitive Na+ current, TTX-resistant Na+ current, and Ca2+ current in the action potentials of nociceptive sensory neurons. Nociceptive sensory neurons are unusual in expressing voltage-gated inward currents carried by sodium channels resistant to block by tetrodotoxin (TTX...
In certain disease processes, voltage-gated calcium channels on autonomic neurons can be targeted; for example antibodies to P/Q-type VGCCs in Lambert–Eaton myasthenic syndrome downregulate VGCCs, thereby inhibiting autonomic neuroeffector transmission. 展开 关键词: ACh, Acetylcholine ATP, Adenosine...