necessary for TRPM2 activation by ADPR73. The enzymatic activity of NUDT9-H is not required for channel gating74, however it plays a role in TRPM2 surface expression75. When expressed on its own, the NUDT9-H domain also has measurable enzymatic activity, thus making TRPM2 a “chanzyme”...
TRPM2 is broadly expressed in neurons. Primary rat cortical cultures exposed to H2O2 undergo rapid apop- totic cell death; treating these neurons with TRPM2 siRNA significantly inhibits H2O2-induced intracellular Ca2+ influx and neuronal cell death[41]. This indicates that neuron-specific TRPM2 ...
Extracellular K +, Na +, and Ca 2+ ions all influence the resting membrane potential of the neuron. However, the mechanisms by which extracellular Na + and Ca 2+ regulate basal neuronal excitability are not well understood. Recent findings suggest that NALCN, in association with UNC79 and UN...
P-type calcium channels in rat central and peripheral neurons The peptide toxin ω-Aga-IVA blocked P-type Ca 2+ channel current in rat Purkinje neurons (K D ≈ 2 nM) but had no effect on identified T-type, L-type, o... IM Mintz,ME Adams,BP Bean - 《Neuron》 被引量: 1517发表:...
Thus, both types of Na+ channels are already established at the early stage of neuronal development and appear to be retained throughout the life-span of the DRG neuron. The concentration-response relationships for the block of TTX-sensitive Na+ current by TTX did not appreciably change during...
Using the whole-cell patch-clamp technique, Ca2+ channel currents were examined in three distinct types of neurons derived from rat primary visual cortex. ... K Giffin,JS Solomon,A Burkhalter,... - 《Neuron》 被引量: 282发表: 1991年 The role of voltage-gated chloride channels in type II...
Here, we systematically examined the relationship between gain and voltage-gated ion channels in a conductance-based, tonically-active, model neuron. Changes in expression (conductance density) of voltage-gated channels increased (Ca2+ channel), reduced (K+ channels), or produced little effect (h-...
Predictably, the metabolic machinery that elicits and responds to changes in intracellular Ca 2+ is correspondingly heterogeneous. This review focuses on one element of this complex web that is of particular importance to neurobiologists: identifying which members of the voltage-dependent Ca 2+ -...
Nerve cells in our nervous system use electrical impulses to transmit signals throughout our body. One way that they do this is through the trafficking of calcium channels through to the outer surface (plasma membrane) of the cell. Calcium entry into a neuron through a calcium channel is a ...
Summary The posterior parietal cortex plays a central role in spatial functions, such as spatial attention and saccadic eye movements. However, recent work... Chris A.,Rishel,and,... - 《Neuron》 被引量: 65发表: 2013年 CROSS-ENCODING OF INFORMATION IN INDEPENDENT CHANNELS. Independent first ...