Voltage gated calcium channels (VGCCs) in sensory neurons, as with almost all excitable cells, are responsible for initiating a variety of cellular processes ranging from transmitter release to changes in gene expression. VGCCs are also a primary target for a number of drugs in current use to ...
Voltage-gated calcium channels are of critical importance for nervous system function at the cellular and network levels. Aberrant calcium channel function is associated with a wide range of neurological and psychiatric conditions. Calcium channel dysfunction can occur as a result of mutations in genes...
Voltage-gated calcium channels have there fore been subject to intense study by numerous investigators over the past few decades, and an immense body of work has accumulated. In this book, we provide the first comprehensive overview of our current state of knowl edge concerning this ...
The intrinsic electrical properties of neurons are shaped in large part by the action of voltage-gated ion channels. Molecular cloning studies have reveale... JS Trimmer,KJ Rhodes - 《Annual Review of Physiology》 被引量: 766发表: 2004年 The role of voltage-gated calcium channels in pancreatic...
Different VGCC subtypes may be coupled to transmitter release at low versus high electrical stimulation frequencies, or in response to potassium depolarization or chemical stimulation. In certain disease processes, voltage-gated calcium channels on autonomic neurons can be targeted; for example antibodies...
30, No 3, 123-130, September 1998 Molecular biology of neuronal voltage-gated calcium channels Hemin Chin Genetics Research Branch, Division of Basic and Clinical Neuroscience Research, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, U.S.A. Accepted 3 August...
Voltage gated calcium channels (VGCCs) are well established mediators of pain signals in primary afferent neurons. N-type calcium channels are localized to synaptic nerve terminals in laminae 1 and 2 of the dorsal horn where their opening results in the release of neurotransmitters such as ...
Voltage-gated ion channels are membrane proteins which underlie rapid electrical signals among neurons and the spread of excitation in skeletal muscle and heart. We outline some recent advances in the study of voltage-sensitive sodium and calcium channels. Investigations are providing insight into the ...
The hypothesis that the entry of extracellular calcium ions into some compartment, quite possibly the type I cells, through voltage-gated calcium channels ... M Shirahata,RS Fitzgerald - 《Journal of Applied Physiology》 被引量: 89发表: 1991年 DOPAMINE MIDBRAIN NEURONS IN HEALTH AND PARKINSON'...
Voltage-gated calcium channels are present in neurons, and in cardiac, smooth, and skeletal muscle and other excitable cells. These channels are known to be involved in membrane excitability, muscle contraction, and cellular secretion, such as in exocytotic synaptic transmission. In neuronal cells, ...