Voltage gated calcium channels (VGCCs) in sensory neurons, as with almost all excitable cells, are responsible for initiating a variety of cellular processes ranging from transmitter release to changes in gene expression. VGCCs are also a primary target for a number of drugs in current use to ...
Different VGCC subtypes may be coupled to transmitter release at low versus high electrical stimulation frequencies, or in response to potassium depolarization or chemical stimulation. In certain disease processes, voltage-gated calcium channels on autonomic neurons can be targeted; for example antibodies...
30, No 3, 123-130, September 1998 Molecular biology of neuronal voltage-gated calcium channels Hemin Chin Genetics Research Branch, Division of Basic and Clinical Neuroscience Research, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, U.S.A. Accepted 3 August...
3.11 Voltage-gated calcium channels Voltage-gated calcium channels are integral to intracellular processes such as contraction, secretion, neurotransmission and gene expression. L-type calcium currents represent the predominant current present in muscle and endocrine cells and also exist in neurons and card...
was detected in excitable cells such as in heart, smooth muscle, and brain [28,29]. In neurons, it is involved in presynaptic function, including the formation and maintenance of synapse, the regulation of synaptic plasticity, and controlling the concentration of calcium in the synaptic cleft [...
Voltage-gated ion channels are membrane proteins which underlie rapid electrical signals among neurons and the spread of excitation in skeletal muscle and heart. We outline some recent advances in the study of voltage-sensitive sodium and calcium channels. Investigations are providing insight into the ...
"Voltage Gated Calcium Channels" is the first comprehensive book in the calcium channel field, encompassing over thirty years of progress towards our understanding of calcium channel structure, function, regulation, physiology, pharmacology, and genetics. This book balances contributions from many of the...
Voltage-gated calcium channels (VGCCs) are membrane proteins and mediate Ca2+ influx in response to membrane depolarization to evoke a wide spectrum of cellular responses, which include neurotransmitter release and activation of Ca2+-dependent enzymes. Molecularly, VGCCs are composed of multiple subunit...
The electrical activity of neurons and other excitable cells relies on a number of different types of voltage- and ligand-gated ion channels that are permeable to inorganic ions such as sodium, potassium, chloride, and calcium. While the former three ions support a predominantly electrogenic role,...
Coriaria lactone increased the intracellular level of calcium through the voltage-gated calcium channels in rat hippocampal neurons[J].Neurochemical Research,2009,(07):1332-1342.Zhang Q, Lai X, Liao D, et al. Coriaria lactone increased the intracellu- lar level of calcium through the voltage- ...