The present invention relates to a combination comprising a plurality of cDNAs which are differentially expressed by DNA methylation in tumor cells and which may be used in their entirety or in part to diagnose, to stage, to treat, or to monitor the treatment of a subject with a disorder ...
DNA methylation is an epigenetic modification of the DNA which regulates gene expression. It plays a significant role in the differentiation of different cell types and it has been shown that DNA methylation patterns are highly tissue-specific12. Although epigenetic alterations represent one of the ha...
DNA methylationunsupervised hierarchical clusteringpromoter methylationBACKGROUND. Pituitary neuroendocrine tumors (PitNETs) are the most common intracranial neuroendocrine tumors. PitNETs can be challenging to classify, and current recommendations include a large immunohistochemical panel to differentiate among 14...
The SOX family regulates alveolar and bronchial differentiation, promotes the formation of pulmonary vasculature, and contributes to pulmonary tissue development. They are closely associated with pulmonary arterial hypertension. SOX2, SOX9, and SOX17 exhibit a synergistic effect on the occurrence and mainte...
Here we report the DNA methylation profile of 84 sporadic pancreatic neuroendocrine tumors (PanNETs) with associated clinical and genomic information. We identified three subgroups of PanNETs, termed T1, T2 and T3, with distinct patterns of methylation.
analyzed data from TCGA and CCGA and identified an association between SOX10 overexpression in glioma and DNA replication, mismatch pair and regulation of negative regulatory T-cell differentiation [155]. Balsas et al. found that SOX11 expression in mantle cell lymphoma (MCL) is correlated with ...
Our analysis of PanNETrevealed frequent loss‐of‐heterozygosity andDNAmethylation at thePHLDA3locus, resulting in strong suppression ofPHLDA3transcription. Such alterations in thePHLDA3gene were also frequently found in lung neuroendocrine tumors (NET), suggesting the possibility that various types of...
www.nature.com/scientificreports OPEN Diagnostic impact of DNA methylation classification in adult and pediatric CNS tumors Laetitia Lebrun1, Nathalie Gilis2, Manon Dausort3, Chloé Gillard4, Stefan Rusu1, Karim Slimani1, Olivier De Witte2, Fabienne Escande5, Florence ...
Chapter 8 addresses three different tumors: medulloblastoma, primitive neuroectodermal tumors, and pineal tumors. The genetic and molecular studies in medulloblastoma are legion; yet, the basic changes responsible for the development of these tumors have
Fig. 1: cfMeDIP data capture cell-free DNA methylation and fragmentation changes in localized vs. mCRPC patient plasma samples. ASampling schematics for the three mCRPC cohorts. Numbers in parentheses indicate the total number of samples in given cohorts. For the Vancouver Prostate Cancer (VPC) ...