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Annu Rev Genet 30:441- 464.Peter W L,Rudolf J.The role of DNA methylation in cancer genetics and epigenetics.Annual Review of Genetics. 1996... PW Laird,R Jaenisch - 《Annual Review of Genetics》 被引量: 959发表: 1996年 Predictors of Refusal to Participate: A Longitudinal Health Survey ...
A comprehensive review describing the key features and plausible functional implications of DNA methylation in the context of colorectal cancer (CRC).Special emphasis is placed on the different methodologies used to distinguish DNA methylation patterns.Explanation and discussion of the clinical significance ...
The patterns of DNA methylation in human cancer cells are highly abnormal and often involve the acquisition of DNA hypermethylation at hundreds or thousands of CpG islands that are usually unmethylated in normal tissues. The recent discovery of 5-hydroxymethylcytosine (5hmC) as an enzymatic oxidation...
However, in recent years there has been a significant growth in our knowledge about the involvement of aberrant patterns of histone modifications in cancer development. In particular, acetylation of lysine residues of histone 3 and histone 4 has become one of the best studied of this type of ...
Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landscape of metastatic cancer has never been defined. Through whole-genome bisulfite sequencing paired with deep whole-genome and transcriptome sequencing of 1
In a study by Batsche E et al [65], dCas9 tool was used to study the role of methylation DNA in the alternative splicing of HCT116 colon cancer cells. They also examined the influence of DNA methylation in MCF10A breast cancer model and ALL patients. dCas9 tool was used to target ...
DNA methylation is of paramount importance for mammalian embryonic development. DNA methylation has numerous functions: it is implicated in the repression of transposons and genes, but is also associated with actively transcribed gene bodies and, in some
Experimental Hematology & Oncology https://doi.org/10.1186/s40164-023-00433-y (2023) 12:69 Experimental Hematology & Oncology REVIEW The role of organoids in cancer research Zhen Fang1,2,3†, Peijuan Li4†, Fengying Du1,2,3†, Liang Shang1,2,3* and Leping Li1,2,3...
Hyperactivation of RAF proteins, particularly BRAF and CRAF, drives tumour progression and drug resistance in many types of cancer. Although BRAF is the most studied RAF protein, partially owing to its high mutation incidence in melanoma, the role of CRAF in tumourigenesis and drug resistance is ...