DNA methylation is an important factor in inducing cancer. There are different types of DNA methylation, and methylation at different sites plays different roles. It is well known that the progression of colorectal cancer (CRC) is affected by the methylation of key genes. The pr...
今天分享的这篇文章基于现有研究总结了癌症DNA甲基化的变化,重点介绍了血液DNA检测对象的特征,包括ctDNA/cfDNA、CTC、外泌体和外周血单核细胞(PBMC),及其在临床研究中的应用。文章标题为:Blood-based DNA methylation signatures in cancer: A systematic revi...
今天分享的这篇文章基于现有研究总结了癌症DNA甲基化的变化,重点介绍了血液DNA检测对象的特征,包括ctDNA/cfDNA、CTC、外泌体和外周血单核细胞(PBMC),及其在临床研究中的应用。文章标题为:Blood-based DNA methylation signatures in cancer: A systematic review。 DNA甲基化是哺乳动物中研究最为深入的表观遗传修饰之一。
aberrant DNA methylation is considered a cancer-associated event。aberrant promoter methylation of several tumor suppressor genes was found in BrC precursor lesions, indicating that DNA methylation is an early event in breast carcinogenesis。DNA methylation has been proposed as a valuable cancer detection ...
Cancer-specific DNA methylation patterns can be detected in tumour-derived free DNA in the bloodstream and in epithelial tumour cells shed into the lumen, offering a promising approach to the early detection of cancer. Clinical application will first require further validation and will ultimately be ...
3. Baylin SB, Jones PA. A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer. 2011;11(10):726-734. doi:10.1038/nrc3130 4. Moss J, Magenheim J, Neiman D, et al. Comprehensive human cell-type methylation atlas reveals origins of circulating...
DNA methylation-based testing in liquid biopsies as detection and prognostic biomarkers for the four major cancer types. Cells 9, https://doi.org/10.3390/cells9030624 (2020). De Borre, M. et al. Cell-free DNA methylome analysis for early preeclampsia prediction. Nat. Med. 29, 2206–2215 (...
[20] REID B M, FRIDLEY B L. DNA methylation in ovarian cancer susceptibility[J]. Cancers, 2020,13(1):108. [21] GUO X M, MILLER H, MATSUO K, et al. Circulating cell-free DNA methylation profiles in the early detection of ovarian...
17.Worm Ørntoft MB (2018) Review of blood-based colorectal cancer screening: how far are circulating cell-free DNA methylation markers from clinical implementation? Clin Colorectal Cancer17, e415– e433. 18.Danese E, Montagnana M & Lippi G (2019) Circulating molecular biomarkers for screening...
2012,Recent Advances in Cancer Research and Therapy Mini review The epigenetics of PBC: The link between genetic susceptibility and environment DNA methylation DNAmethylationinvolves the addition of amethyl grouptocytosinesbyDNA methyl transferases(Dnmts)[74].DNA methylationvaries among tissues and cell...