利用外周血进行cfDNA甲基化检测是近年来针对肿瘤早期进行无创诊断的重要方式。2008年已有研究证实结肠癌组织SEPTIN9基因启动子存在不同程度甲基化,并提出外周血SEPTIN9 甲基化可用于结直肠癌(colorectal cancer ,CRC)早期筛查 。2024年,《新英格兰医学杂志...
aberrant DNA methylation is considered a cancer-associated event。aberrant promoter methylation of several tumor suppressor genes was found in BrC precursor lesions, indicating that DNA methylation is an early event in breast carcinogenesis。DNA methylation has been proposed as a valuable cancer detection ...
Methylation analyses in liquid biopsy[J]. Transl Lung Cancer Res,2016,5(5):492⁃504. [5] LUO H,WEI W,YE Z,et al.Liquid Biopsy of Methylation Biomarkers in Cell⁃Free DNA[J].Trends Mol Med,2021,27(5):482⁃500. [6] MARRUGO⁃RAMÍREZ J,MIR M,SAMITIER J.Blood⁃Based ...
[25] SHEN Z, CHEN C, SUN J, et al. The status of WIF1 methylation in cell-free DNA is associated with the insusceptibility for gefitinib in the treatment of lung cancer [J]. J Cancer Res Clin Oncol, 2021, 147(8): 2239-48. [26] LEE D H, HWANG S A-O, LIM M K, et al....
DNA Methylation NGS Basics for Cancer Research Introduction: What is DNA methylation? DNA methylation is one of the most common and most studied epigenetic processes, which alters gene expression without changing the DNA sequence. Within the mammalian genome, meth...
12. Barault L, Amatu A, Bleeker FE, et al. Digital PCR quantification of MGMT methylation refines prediction of clinical benefit from alkylating agents in glioblastoma and metastatic colorectal cancer. Ann Oncol Off J Eur Soc Med Oncol. 2015;26(9):1994-1999. doi:10.1093/annonc/mdv272 ...
会议上,复旦大学附属中山医院樊嘉院士、周俭教授等领衔的研究团队与鹍远生物共同报道了一种基于血液ctDNA甲基化信号的肝癌早诊方法-HepaAiQ™(大会摘要号:Abstract:4103)[1]。 研究结果显示:HepaAiQ™检测性能优异,在健康人群中的特异性为93.4%、肝癌诊断的灵敏度高达87.2%,尤其对于早期肝癌也显示出优异诊断性能(灵...
DNA Methylation Analysis of the SHOX2 and RASSF1A Panel in Bronchoalveolar Lavage Fluid for Lung Cancer Diagnosis. J Cancer. 2017;8(17):3585-3591. doi:10.7150/jca.21368 7. Liang W, Chen Z, Li C, et al. Accurate diagnosis of pulmonary nodules using a noninvasive DNA methylation test. ...
本次会议上,复旦大学附属中山医院樊嘉院士、周俭教授等领衔的研究团队与鹍远生物共同报道了一种基于血液ctDNA甲基化信号的肝癌早诊方法-HepaAiQ(大会摘要号:Abstract:4103)[1],研究结果显示HepaAiQ检测性能优异,在健康人群中的特异性为93...
随着生物医学的发展,DNA甲基化(DNA methylation)标志物在癌症诊断、治疗选择及预后评估中的重要性日益凸显。本专家共识旨在全面梳理DNA甲基化标志物的检测技术、临床应用及其在肿瘤管理中的潜力。此外,本共识将围绕DNA甲基化标志物的定义、临床意义、检测规范、数据处理及其在肿瘤的筛查、辅助诊断、伴随诊断及复发监测中的...