In our laboratory, we have carried out methylation analysis of 14 different tumor suppressor genes in cell-free DNA from the peripheral blood of over 1400 cancer patients, and have detected more than a total of 1900 methylations. We performed an analysis of DNA methylations of 14 different ...
近日,来自美国德州大学安德森癌症中心的John V. Heymach与Lauren A. Byers团队,在Cancer Cell期刊发表题为Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes的文章。研究人员构建了高鲁棒性较的...
Tumor-derived circulating cell-free DNA (cfDNA) provides critical clues for cancer early diagnosis, yet it often suffers from low sensitivity. Here, we present a cancer early diagnosis approach using tumor fractions deciphered from circulating cfDNA methylation signatures. We show that the estimated ...
2023年9月7日,北京大学人民医院王俊院士与团队的陈克终教授在Cancer Cell上发表了文章Individualized tumor-informed circulating tumor DNA analysis for postoperative monitoring of non-small cell lung cancer,公布了首个早期肺癌头对头对比...
Cell-Free DNA Methylation: The New Frontiers of Pancreatic Cancer Biomarkers' Discovery 来自 NCBI 喜欢 0 阅读量: 31 作者:M Brancaccio,F Natale,G Falco,T Angrisano 摘要: Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal cancer types world-wide. Its high mortality is related to ...
Heymach团队在Cancer Cell上发表题为: Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes的研究性论文。 小细胞肺癌(SCLC)是一种由不同的转录亚型组成的侵袭性恶性肿瘤,但在临床实施亚型仍具有挑战性,特别是由于有限的组织可用性。鉴于已知的SCLC关键转录程序...
Multimodal epigenetic characterization of cell-free DNA (cfDNA) could improve the performance of blood-based early cancer detection. However, integrative profiling of cfDNA methylome and fragmentome has been technologically challenging. Here, we adapt an enzyme-mediated methylation sequencing method for com...
Early detection of the three major primary cancers in women by cell-free DNA methylation in liquid biopsies BACKGROUND Gastrointestinal tumors are among the most common cancer types,and early detection is paramount to improve their management.Cell-free DNA(cfDNA)... SP Nunes 被引量: 0发表: 2018...
Cell-free DNA (cfDNA) analysis represents a promising method for the diagnosis, treatment selection and clinical follow-up of cancer patients. Although its general methodological feasibility and usefulness has been demonstrated, several issues related to standardisation and technical validation must be addr...
In many areas of oncology, we lack sensitive tools to track low-burden disease. Although cell-free DNA (cfDNA) shows promise in detecting cancer mutations, we found that the combination of low tumor fraction (TF) and limited number of DNA fragments restr