然而在已知的近100多种中枢神经系统肿瘤(central nervous system tumor,CNS tumor,简称“CNS肿瘤”)中,相关标准化的诊断面临很大的挑战。 2月15日,Nature杂志以长文形式发表了德国海德堡大学医院、德国癌症研究中心等单位上百名科学家联合完成的题为“DNA methylation-based classification of central nervous system tumo...
然而在已知的近100多种中枢神经系统肿瘤(central nervous system tumor,CNS tumor,简称“CNS肿瘤”)中,相关标准化的诊断面临很大的挑战。 3月14日,Nature杂志以长文形式发表了德国海德堡大学医院、德国癌症研究中心等单位上百名科学家联合完成的题为“DNA methylation-based classification of central nervous system tumo...
然而在已知的近100多种中枢神经系统肿瘤(central nervous system tumor,CNS tumor,简称“CNS肿瘤”)中,相关标准化的诊断面临很大的挑战。 3月14日,Nature杂志以长文形式发表了德国海德堡大学医院、德国癌症研究中心等单位上百名科学家联合完...
Formalin-fixed paraffin-embedded (FFPE) meningioma tumor samples were processed, loaded onto the Infinium Methylation EPIC array, and scanned using the Illumina IScan system. Raw IDAT files were processed through the the CNS tumor classifier developed by the Molecular Neuropathology group at the German...
已知的中枢神经系统肿瘤(central nervous system tumor, CNS tumor)类型大约有100种,这么多的种类给医生的诊断带来了极大挑战,而诊断的准确性对于肿瘤的治疗至关重要。研究者开发了一个机器学习程序,训练参照数据采用德国肿瘤国家中心(NCT)的2801名癌症患者的DNA甲基化实验数据(DNA甲基化芯片结果)。这些患者涵盖了各种脑...
The DNA methylation field has matured from a phase of discovery and genomic characterization to one seeking deeper functional understanding of how this modification contributes to development, ageing and disease. In particular, the past decade has seen many exciting mechanistic discoveries that have subst...
New brain tumor entities emerge from molecular classification of CNS-PNETs. Cell 164, 1060–1072 (2016) Article CAS Google Scholar Fernandez, A. F. et al. A DNA methylation fingerprint of 1628 human samples. Genome Res. 22, 407–419 (2012) Article CAS Google Scholar Hovestadt, V. ...
Another research revealed significantly reduced DNA methylation of tumor necrosis factor-α (TNF-α) in the promoter region of TG in temporomandibular joint inflammatory pain, which resulted in the up-regulation of TNF-α [9]. Despite the research on the role of some specific genes DNA ...
(Ceccarelli et al., 2016). A recent study suggests a new DNA methylation-based classification ofCNS tumors, offering a novel approach totumor classificationand diagnosis precision, further strengthening the importance of comprehending and assessing the cancermethylomeand thus theepigenetic mechanismsthat ...
During development, DNA methylation patterns shape the differentiation of cells, ensuring the emergence of distinct cell types with specialized functions. Aberrancies in these patterns have been implicated with cancer and other maladies. For instance, hypermethylation of tumor suppressor ...