Circulating tumor DNA methylation: a promising clinical tool for cancer diagnosis and managementdoi:10.1515/cclm-2023-1327cancerctDNAmethylationdetection technologyearly diagnosisCancer continues to pose significant challenges to the medical community. Early detection, accurate molecular profiling, and adequate...
The low abundance of circulating tumour DNA (ctDNA) in plasma samples makes the analysis of ctDNA biomarkers for the detection or monitoring of early-stage cancers challenging. Here we show that deep methylation sequencing aided by a machine-learning cla
DNA methylation markers for diagnosis and prognosis of common cancers. Proc. Natl Acad. Sci. USA 114, 7414–7419 (2017). Article CAS Google Scholar Aravanis, A. M., Lee, M. & Klausner, R. D. Next-generation sequencing of circulating tumor DNA for early cancer detection. Cell 168, ...
Circulating tumor DNA (ctDNA)encapsulates genetic features linked to tumor cells, encompassing mutations, methylation patterns, insertions, rearrangements, and copy number abnormalities. It emerges as a crucial indicator for tumor screening, companion diagnostics, assessing therapeutic efficacy, and stratifying...
Diagnostic performance and prognostic value of circulating tumor DNA methylation marker in extranodal natural killer/T cell lymphoma Cell Rep Med, 4 (2) (2023), Article 100859 View PDFView articleView in ScopusGoogle Scholar [53] S Suwiwat, J Pradutkanchana, T Ishida, W. Mitarnun Quantitative...
Together, our patient PFS analysis revealed that CTC cluster-associated hypomethylated regions are also hypomethylated at the level of the primary tumor in a subset of breast cancer patients characterized by a poor prognosis, compared to patients that display higher methylation levels in the same regio...
Early Detection of Molecular Residual Disease and Risk Stratification for Stage I to III Colorectal Cancer via Circulating Tumor DNA Methylation Shaobo Mo, MD1,2;Li Ye, MD1,2;Dongyang Wang, MD3;et alLingyu Han, MD1,2;Shuang Zhou, PhD4;Hui Wang, PhD4;Weixing Dai, MD1,2;Yichao Wang, MD...
Next-generation sequencing (NGS) of tumour tissue DNA is emerging as a promising avenue to comprehensively characterize tumour mutation burden. High nonsynonymous tumor mutational burden (TMB), evaluated by WES has shown to correlate with improved clinical outcomes for patients with other types of canc...
circulating tumor cells (CTCs). One critical process, DNA methylation, regulates gene expression and chromosome stability, thus maintaining dynamic equilibrium in the body. Global hypomethylation and locus-specific hypermethylation are examples of changes in DNA methylation patterns that are pivotal to ...
N. et al. Prevalence of clonal hematopoiesis mutations in tumor-only clinical genomic profiling of solid tumors. JAMA Oncol. 4, 1589–1593 (2018). Article Google Scholar Li, Y. S. et al. Unique genetic profiles from cerebrospinal fluid cell-free DNA in leptomeningeal metastases of EGFR-...