Glioma is the most common primary malignant brain tumor. Despite significant advances in the past decade in understanding the molecular pathogenesis of thi
In contrast, liquid biopsy is a noninvasive, ideal surrogate for tissue biopsy that can identify circulating tumor DNA (ctDNA) containing tumorigenic signatures. It has been successfully implemented to assist treatment decisions and disease outcome prediction. ctDNA methylation, a type of lipid biopsy...
Circulating tumor DNA (ctDNA)encapsulates genetic features linked to tumor cells, encompassing mutations, methylation patterns, insertions, rearrangements, and copy number abnormalities. It emerges as a crucial indicator for tumor screening, companion diagnostics, assessing therapeutic efficacy, and stratifying...
where tumor cells migrate through the bloodstream from the original site to other parts of the body. Recent advancements in technology have significantly enhanced our comprehension of the mechanisms behind the bloodborne spread of circulating tumor cells (CTCs). One critical process, DNA methylation, ...
. They found similar DNA methylation profiles between tumour tissue and serum DNA (21 and 50 respectively). For those patients with serum positive hypermethylated DNA, 5 out of 21 developed recurrence, while only 1 out of 29 patients who relapsed had negative serum methylation DNA [127]. Tian...
et al. mRNA-Seq of single prostate cancer circulating tumor cells reveals recapitulation of gene expression and pathways found in prostate cancer. PLoS ONE 7, e49144 (2012). Article CAS PubMed PubMed Central Google Scholar Asare, A. L. et al. Differential gene expression profiles are dep...
Blood testing using Circulating Tumor Cells (CTCs) has emerged as one of the hottest fields in cancer diagnosis. Research on CTCs present nowadays a challe
These data establish that tumor and cfDNA methylation can be used to identify SCLC subtypes and might guide precision SCLC therapy. 展开 关键词: EXPRESSION PROFILES OUTCOMES NEUROD1 ASCL1 SEQ DOI: 10.1016/j.ccell.2024.01.001 年份: 2024
circulating tumor DNA; circulating cell-free DNA; liquid biopsy; DNA methylation; colorectal cancer; surgery; prognosis; survival; systematic review1. Introduction Surgical resection remains the cornerstone of treatment in non-metastatic colorectal cancer (CRC) patients. Optimal reduction in recurrence ...
N. et al. Prevalence of clonal hematopoiesis mutations in tumor-only clinical genomic profiling of solid tumors. JAMA Oncol. 4, 1589–1593 (2018). Article Google Scholar Li, Y. S. et al. Unique genetic profiles from cerebrospinal fluid cell-free DNA in leptomeningeal metastases of EGFR-...