Prior to this study, no specific transcription factor footprints had been observed over proximal elements of any snRNA gene. Footprints were also found over elements A and E. The results of the computer search and the footprinting are discussed in light of what is known about snRNA promoter ...
LETTERS TO NATURE Specific binding of the transcription factor sigma-54 to promoter DNA Martin Buck & Wendy Cannon AFRC Nitrogen Fixation Laboratory, University of Sussex, Brighton BN1 9RQ, UK A CENTRAL event in transcription is the assembly on DNA of specific complexes near the initiation sites...
We studied the interaction of nuclear proteins with the 5'-flanking and promoter region of the human cellular retinol binding protein 1 (hCRBP1) gene and i... W Eskild,J Simard,V Hansson,... - 《Molecular Endocrinology》 被引量: 47发表: 0年 A nuclear factor induced by hypoxia via de...
研究也可以做得很深,了解一个物种里面有哪些transcription factor families,这些转录因子各自是如何发挥作用的,这些家族是如何归类的,各自有什么特性。 TRANSCRIPTION FACTORS: Structural Families and Principles of DNA Recognition【非常古老的综述1992年,也非常有意思,涉及了TF binding的本质,而不是浮在表面】 Arabidopsi...
Zinc finger transcription factor 191, directly binding to β-catenin promoter, promotes cell proliferation of hepatocellular carcinoma Zinc finger transcription factor 191, directly binding to β-catenin promoter, promotes cell proliferation of hepatocellular carcinoma. Liu G,Jiang S,Wang C... Liu,Jiang...
For each promoter, all of its known cis-elements are listed according to their positions, while these cis- elements are aligned to illustrate their consensus sequence for each transcription factor. All probable transcription factors coded in the genome were classified with the Pfam motifs. Using ...
Pluripotent stem cells provide a powerful system to dissect the underlying molecular dynamics that regulate cell fate changes during mammalian development. Here we report the integrative analysis of genome-wide binding data for 38 transcription factors w
Transcription factors are thought to regulate the transcription of microRNA genes in a manner similar to that of protein-coding genes; that is, by binding to conventional transcription factor binding site DNA sequences located in or near promoter regions that lie upstream of the microRNA genes. ...
Here, using a massively parallel reporter assay (MPRA) of 209,440 sequences, we examine all possible pair and triplet combinations, permutations and orientations of eighteen liver-associated transcription factor binding sites (TFBS). We find that TFBS orientation and order have a major effect on ...
We found that promoter regions of Runx1 and Runx3 are targets of STAT4 and that STAT4 binding during NK cell activation induces epigenetic modifications of Runx gene loci resulting in increased expression. Furthermore, specific ablation of Runx1, Runx3, or their binding partner Cbfb in NK ...