Furthermore, our picture of promoter control has evolved beyond one in which regulation results solely from activators and repressors that bind to DNA sequences near the RNAP binding site: many important transcription factors bind directly to RNAP without binding to DNA. These factors can target ...
p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, ...
p53 is up-regulated in response to stress signals and stimulated to activate transcription of specific genes, resulting in expression of p21waf1 and other proteins involved in G1 or G2/M arrest. The structure of p53 comprises an N-terminal transactivation domain, a central DNA-binding domain, ...
E2 keeps the expression of E6 and E7 low by binding to their promoter and thus blocking the access to transcription factors until the cells begin the process of differentiation and migration up through the suprabasal layers of the epithelium [14]. As this occurs, E6 and E7 expression is up...
Furthermore, the N-terminus of APE1 grants it redox regulation, which allows it to control gene expression though regulation of transcription factors (such as p53, AP-1, and HIF-1α) [143]. 4.1.3. Repair Synthesis The removed nucleotide needs to be replaced by a DNA polymerase. A 3′...
http500错误 http 500内部服务器错误,请与管理员联系。 请尝试以下操作: ·打开主页,然后查找指向您感兴趣信息的链接。 ·单击后退链接,尝试其他链接。
Trans -acting factors from the nuclear proteins of the cell are able to positively or negatively regulate transcription of these genes by binding to highly conserved sequences, called boxes. After cloning the promoter regions of all the transcribed class II B genes present in the cell line Pr...
The variable recruitment of transcription factors to the same cis element under different cellular conditions may represent a mechanism underlying the tight link between keratinocyte differentiation and E6/E7 expression. 展开 关键词: Gene Expression Regulation, Viral Papillomavirus, Human Virus Replication ...
Human TAF(II)55 (hTAF(II)55), a component of the general transcription factor TFIID, is the only general transcription factor encoded by an intronless gene identified thus far. Analysis of the TATA-less hTAF(II)55 promoter-proximal sequence reveals putative binding sites for STAT-1, MEF2,...
In this network, CBF (C-repeat binding factor) transcription factors are considered as master molecular switches. CBFs specifically bind to the DRE/CRT (dehydration-responsive element/C-repeat element, A/GCCGAC) cis-acting regulatory element of the promoter region of the cold-responsive genes, ...