aHowever, eukaryotic transcription factors may also bind to DNA sequences known as enhancers that may be thousands of base pairs away from the promoter. 然而, eukaryotic副本因素也许也束缚到脱氧核糖核酸序列以也许是数以万计基本的对去从促进者的改进物著名。[translate] ...
Thus, it may be inappropriate to draw conclusions that underestimate the potential of EPR effects in nanomedicines before understanding the interactions that influence the fate of nanoparticles in biological systems. In fact, the strategy of applying EPR-effect enhancers has been increasingly discussed, ...
Trans-acting transcription factors bind to cis-regulatory DNA sequences, which regulate the expression of genes on the same DNA molecule. It has long been suspected that Mediator also links up proximal or distal cis-regulatory elements, such as enhancers, with th...
A fourth conserved region was localized to the proximal promoter around an E-box motif and was found to bind members of the upstream stimulatory factor (USF) family of transcription factors. We postulate that disruption of pdx-1 cis-acting regulatory seq...
Eukaryotic promoters are made up of a number of sequence elements spread over about 200 bp upstream from the transcription start site. In addition to promoters, enhancers also influence the expression of genes. Control of gene expression in eukaryotes involves many more factors than control in proka...
“triple helix” base-pairing methodology. Triple helix pairing is useful because it cause inhibition of the ability of the double helix to open sufficiently for the binding of polymerases, transcription factors, or regulatory molecules. Recent therapeutic advances using triplex DNA have been described...
Control is Hierarchical and Combinatorial Different combinations of transcription factors make possible a very large number of different control signals – Genome-wide expression studies seem to indicate that each gene has at least slightly different control. Different regulatory factors must interact with ...
BackgroundProteins encoded by the v-Rel viral oncogene and its cellular homolog, c-Rel, are members of a family of transcription factors that include the two subunits of the transcription factor NF kB (p50 and p65) and the Drosophila maternal morphogen, dorsal. Both proteins specifically bind ...
Factors Affecting HERV Transcription Systemic Immune Activation and Inflammation HERV promoter regions possess binding sites for a range of transcription factors involved in regulating the duration and intensity of the immune response. Such transcription factors include GATA factors (which bind the GATA DNA...
分子生物学transcriptiontafiis导论repressorinitiation 1/76 Chapter4TranscriptioninEukaryotes: MechanismandRegulation 4.1EukaryoticRNA polymerases 4.2EukaryoticPromoters 4.3GeneralTranscription FactorsandInitiation 4.4SpecificTranscriptionFactors andTranscriptionalRegulation 4.5Structuresofspecific transcriptionfactors 4.6Experiments...