This review describes some of the models proposed to explain the physical role of enhancers in eukaryotic transcription.doi:10.1002/bies.950080404Kuan㏕eh JeangGeorge KhouryJohn Wiley & Sons, Ltd.BioessaysJeang KT, Khoury G. The mechanistic role of enhancer elements in eukaryotic transcription. Bio...
To assess the role of transcriptional enhancers in regulating accessibility of the T-cell receptor beta-chain (TCRbeta) locus, we generated embryonic stem ... J C,Bories,Demengeot,... - 《Proceedings of the National Academy of Sciences of the United States of America》 被引量: 273发表: ...
The role of enhancers as centres for general transcription factor recruitment. Activation of eukaryotic genes requires a tight temporal control of trans-acting-factor binding to different types of sequence elements. General transcript... H Szutorisz,N Dillon,L Tora - 《Trends in Biochemical Sciences...
Mediator complex has been extensively shown to regulate the levels of several protein-coding genes; however, its role in the regulation of miRNAs in humans remains unstudied so far. Here we show that MED1, a Mediator subunit in the Middle module of Media
Whole-genome bisulfite sequencing (WGBS) analysis revealed that Tet-mediated DNA demethylation mainly occurs at distally located enhancers and fine-tunes the transcription of genes associated with these regions. Functional characterization of Tet TKO ESCs revealed a role for Tet proteins in regulating ...
High level expression in mice of transgenes derived from the immunoglobulin heavy chain (IgH) locus requires both the core enhancer (Eμ) and the matrix attachment regions (MARs) that flank Eμ. The need for both elements implies that they each perform a different function in transcription. Wh...
DNA methylation of transcriptional enhancers and cancer predisposition. Cell 154, 11–13 (2013). CAS PubMed Google Scholar Hnisz, D., Day, D. S. & Young, R. A. Insulated neighborhoods: structural and functional units of mammalian gene control. Cell 167, 1188–1200 (2016). CAS PubMed ...
Functionally, we find that TDG both sensitizes MCF7 cells to tamoxifen-mediated cytostasis and increases migration and invasion of MCF7 cells. Taken together we find that TDG plays a central role in mediating transcription at a subset of enhancers and governs how MCF7 cells respond to both ...
Abstract 405: Mbd3 localizes at promoters, gene bodies and enhancers of active genes The structure of chromatin is tightly regulated; its disregulation is causal for developmental abnormalities and for cancer. The nucleosome remodeling and deacetylase (NuRD) complex regulates chromatin structure and gene...
Using comparative analysis between human and mouse, we identified conserved regions 3′ of the transcription unit, including the / endodermal enhancers and elements within a 4.2-kb domain between the transcription unit and the enhancers. Transgene experiments implicate these elements in imprinting ...