Specifically, super-enhancers are clusters of enhancers defined based on the binding occupancy of master transcription factors, chromatin regulators, or chromatin marks, while stretch enhancers are large chromatin-defined regulatory regions of at least 3,000 base pairs. Several studies have characterized ...
To test whether active loop extrusion is essential for maintaining various types of chromatin loops and transcription, we endogenously and homozygously tagged each of the three primary loop extrusion factors (CTCF, RAD21 or WAPL) with an auxin-inducible degron (AID) by clustered regularly repeating...
Taken together, these data suggest a potential role for the AP1 transcription factors in the maintenance of the peripheral taste system. AP1 transcription factors are downregulated in CV/Fol taste cells from 6-month-old mice. We validated the differences in the expression of c-Fos, c-Jun and ...
The sequence motif CGTCA is critical for binding of a group of cellular transcription factors (ATF, CREB, E4F, and EivF) and for activation of certain E1a-inducible and cyclic AMP (cAMP)-inducible promoters. We have tested different promoter elements containing the CGTCA motif (referred to ...
The acetyltransferase activity is dispensable for the recruitment of p300/CBP and transcription factors but essential for promoting the recruitment of TFIID and RNAPII at virtually all enhancers and enhancer-regulated genes. This identifies pre-initiation complex assembly as a dynamically controlled step ...
Stem and multipotent progenitor cells show scant H3K4me2 marking at enhancers bound by specific transcription factors in their committed progeny. Rather, enhancers are modulated dynamically and serially, with substantial loss and gain of H3K4me2, at each cellular transition. Quantitative analysis of ...
Thus, no simple relationship emerged from these studies of other transcription factors and regulatory pathways that might explain the variable expression of MITF, SILV, and MLANA among melanomas. Analysis of SILV, MLANA and MITF Expression in Tumor Microarrays Several of the cell lines used in our...
enhancers,12% exhibited cell type/tissue-specific enrichment in fetal heart and muscle tissue. Together, our conclusions supply additional insights to the genome-wide Ppp1r1b-lncRNA Chromatin interactome that may potentially influence its function in myogenic differentiation and potentially other mobile ...
Researchers studying transcription have identified and characterized Epromoters: gene promoters that also act as enhancers for distal genes
Position-dependent function of human sequence-specific transcription factors Article Open access 17 July 2024 Introduction Gene regulatory sequences are a major cause of human disease1. More than 90% of disease-associated variants are found in non-coding regions of the human genome2,3,4. However...