which is mediated by the pausing components DRB sensitivity-inducing factor (DSIF) and negative elongation factor (NELF). Paused RNA Pol II is released by the kinase activity of positive transcription elongation factor b (P-TEFb), which phosphorylates DSIF and NELF, altering the suppressive...
YY1 has been proposed as a structural regulator of E–P loops, but acute YY1 depletion also had minimal effects on E–P loops, transcription and 3D genome folding. Strikingly, live-cell, single-molecule imaging revealed that cohesin depletion reduced transcription factor (TF) binding to chromatin...
Transcriptional enhancer factor (TEF)-1 and transcriptional intermediary factor (TIF) are active in human keratinocytes: Are they involved in keratinocyte-specific transcription?Human papillomaviruses (HPVs) are common DNA viruses in humans. Recently, epithelial cancers associated with HPV infection have ...
an enhancer of the transcription factor BCL11A indirectly regulates the expression of fetal hemoglobin genes [73,74], and an enhancer harboring breast cancer associated variants regulates ESR1 and further regulates cancer regulated pathways [29]. In this way, BC-associated...
tumor samples comparing two subtypes of HPV-associated head and neck cancer, and ATAC-seq and RNA-seq datasets studying overexpression of the transcription factor Sox17 in the same cells (see “14”). In both cases, the top ranked EnTDefs with the regulome data were better able to ...
Enhancers are broadly conceptualized as short regions of DNA that increase the likelihood of gene transcription at one or more cis loci, typically by facilitating chromatin remodeling and promoting transcription factor (TF) binding (11). Enhancers are often identified in genome-scale assays by their ...
Lymphoid enhancer-binding factor 1 (LEF-1) is a transcription factor of the Wingless-type (Wnt)/β catenin signaling pathway which controls the proliferation, survival, and differentiation of hematopoietic cells through its effect on target genes like c-myc, cyclin D1 [1]. In normal human ...
One of the most common forms of functional interaction among transcription factors is the more than additive effect at promoters harboring multiple copies ... L Subramanian,MD Benson,Jorge A Iiguez-Lluhí - 《Journal of Biological Chemistry》 被引量: 595发表: 2003年 Functional Antagonism between ...
Understanding the contributions of transcription factor DNA binding sites to transcriptional enhancers is a significant challenge. We developed Quantitative enhancer-FACS-Seq for highly parallel quantification of enhancer activities from a genomically in
Gene expression is important duringdevelopmentascellsestablish their identity and become various cell types with distinct functions. The transcription factor Vsx2 is essential to proper eye development. It is expressed in retinal progenitor cells and found in established bipolar neurons and Müller gl...