The establishment of naive pluripotency is a continuous process starting with the generation of inner cell mass (ICM) that then differentiates into epiblast (EPI). Recent studies have revealed key transcription factors (TFs) for ICM formation, but which
(1996). Transcription factor recognition surface on the RNA polymerase α subunit is involved in contact with the DNA enhancer element. EMBO J 15, 4358-4367.K. Murakami, N. Fujita, A. Ishihama, Transcription factor recogni- tion surface on the RNA polymerase K subunit is involved in contact...
In this study, we identified the transcription factor c-Maf as a universal regulator of Tγδ17 cell differentiation and maintenance. Maf deficiency caused an absolute lineage block at the immature CD24+CD45RBloγδ thymocyte stage, which revealed a critical checkpoint in the acquisition of ...
More recently we have shown that transcriptional enhancer factor 4 may stimulate the expression of the CTα gene (27). Lagace et al. (24) have shown that the sterol response element-binding protein stimulates PC biosynthesis indirectly but does not appear to alter transcription of the CTα ...
Furthermore, multivariate analysis confirmed that low ATF3/GDF15 but not a single low expression of ATF3 is an independent prognostic factor for progression-free survival of bladder cancer patients, concluding that a positive correlation mutually existed in both ATF3 and GDF15 expressions in bladder...
CAT assays investigating the transcriptional activity of the first intron of EGFR indicate that a 140 bp region has an enhancer ability specifically in these hormone-independent breast cancer cells. The DNA-protein interaction that occurs in this enhancer was localized to a 35 bp region and ...
Two other enhancer traps, DJ717-Gal4 and DJ691-Gal4, are also expressed in a pattern throughout the midgut. One enhancer trap, CB30, an insertion into the Tab2 transcription factor gene involved in the Drosophila innate immune response [23, 29], expressed throughout all circular muscles, ...
AURKA is predominantly famous as an essential mitotic kinase. Recent findings have also established its critical role in a plethora of other biological processes including ciliogenesis, mitochondrial dynamics, neuronal outgrowth, DNA replication and cell
In summary, the core promoter is characterized by a nucleosome-depleted region followed by a strongly positioned +1 nucleosome that overlaps the transcription start site. The coding region is packaged by an array of nucleosomes with increasingly fuzzy positioning towards the 3′ end. Finally, ...
like macrophages, or overexpression of miR-101 inhibits CCAAT/enhancer binding protein α (C/EBPα) and KLF6 production, which induces polarization from M1 to M2 phenotype40. Antitumor therapeutic strategies regulating M1/M2 polarization are promising due to the superior plasticity of TAMs....