Transcription factors bind to the DNA upstream of a gene (promoter and enhancer sequences), “attracting” RNA polymerase to the site. ▸RNA pol (and friends) scan dsDNA in the nucleus, find and bind to now-available promoter region, initiating transcription. ▸Single-stranded messenger RNAs...
Different sets of transcription factors bind to Prnd promoter in N2a and GC-1 spg cells determined by gel-shift analyses with the nuclear extract (NE) from GC-1 spg and N2a cells.Kefeng, QinTianbing, D...
ABA perception and signaling are major factors limiting apple production. To test whether MdWRKY31 was involved in the response to ABA in apple,MdWRKY31was first fused to the expression vector PRI-GFP along with the strong35Spromoter upstream. The35S::MdWRKY31-GFPconstruct was then transformed ...
Binding of transcription factors to their specific binding motifs in the promoter region may alter transcription by interacting directly with components of the basal transcription apparatus or via cofactors that link the transcription factor to the basal transcription apparatus [14]. Large proteins that ...
Octamer-binding transcription factor 4 (Oct4, also known as Pou5F1 or Oct3/4) is a nuclear protein that is part of a family of transcription factors containing the POU DNA binding domain. These types of transcription factors will bind to the promoter or enhancer regions of target g...
Transcription factor, molecule that controls the activity of a gene by determining whether the gene’s DNA is transcribed into RNA. Transcription factors control when, where, and how efficiently RNA polymerases, which catalyze the reactions that synthesi
Incessant telomere synthesis in cancer cells depends on specific mutations in the TERT promoter, enabling its activation by transcription factors ETS1 and p52. Here, the authors elucidate the structural basis for p52/ETS1 binding to mutant TERT, suggesting a general mechanism for TERT reactivation in...
Octamer transcription factors 1 and 2 each bind to two different functional elements in the immunoglobulin heavy-chain promoter. 喜欢 0 阅读量: 12 作者:L Poellinger,RG Roeder 摘要: Immunoglobulin heavy-chain genes contain two conserved sequence elements 5' to the site of transcription initiation:...
DNA transcriptionto mRNA is regulated by regulatory proteins, called transcription factors, which bind to specificDNA sequencesclose to the gene. Transcription factors bind to short (5–20 bp)promoter regionsof DNA that are usually within a few hundred base pairs of the site where transcription st...
Pluripotent stem cells provide a powerful system to dissect the underlying molecular dynamics that regulate cell fate changes during mammalian development. Here we report the integrative analysis of genome-wide binding data for 38 transcription factors w