本文提介绍了scFAN(single-cell factor analysis network单细胞因子分析网络),这是一种深度学习模型,可以预测单个细胞中全基因组的转录因子结合网络。 scFAN包括对大量的数据进行“预训练模型”训练,然后使用DNA序列数据,汇总的相似scATAC-seq数据和可定位性数据的组合,将其用于预测单细胞水平上的转录因子结合。 scFAN...
Incubates which include candidate agents which alter transcription factor binding deviate from control incubates in terms of label signal--typically, binding is disrupted and the signal is diminished. In a preferred embodiment, the entire process is performed by a computer-controllable electromechanical ...
Pluripotent stem cells provide a powerful system to dissect the underlying molecular dynamics that regulate cell fate changes during mammalian development. Here we report the integrative analysis of genome-wide binding data for 38 transcription factors w
In Wiki format, factorbook is a transcription factor (TF)-centric repository of all ENCODE ChIP-seq datasets on TF-binding regions, as well as the rich analysis results of these data. In the first release, factorbook contains 457 ChIP-seq datasets on 119 TFs in a number of human cell ...
The SOX2 pioneer transcription factor performs critical roles in pluripotency and self-renewal of embryonic stem cells. Here the authors show that SOX2’s two nuclear localization signal sequences form a contiguous binding interface on the nuclear import receptor importin-α3, and provide a structural...
Transcription factor bindingmotifs within these regions were mapped with the help of the MatInspector and TFSEARCH programs. Factors implicated in ... BK Nandagopal - 《Cellular & Molecular Neurobiology》 被引量: 25发表: 2007年 UCP2 and 3 Deletion Screening and Distribution in 15 Pig Breeds We...
Different Domains of the Transcription Factor ELF3 Are Required in a Promoter-specific Manner and Multiple Domains Control Its Binding to DNA 来自 掌桥科研 喜欢 0 阅读量: 52 作者:JL Kopp,PJ Wilder,M Desler,L Kinarsky,A Rizzino 摘要: Elf3 is an epithelially restricted member of the ETS ...
【文献报告】Mammalian evolution of human cis-regulatory elements and transcription factor binding sites 该研究旨在通过对241个哺乳动物基因组的参考无序比对,绘制0.92百万个人类候选顺式调控元件(cCREs)和15.6百万个人类转录因子结合位点(TFBSs)的进化轨迹。研究发现,有439,461个cCREs和2,024,062个TFBSs处于进化...
and apoptosis of various cell types includingkeratinocytes, is a major event in psoriasis, contributing to the hyperproliferative phenotype by induction of heparin-binding EGF-like growth factor, known to induce epidermalhyperplasiaand be overexpressed in psoriasis. In primary keratinocytes of psoriatic le...
While footprinting analysis of ATAC-seq data can theoretically enable investigation of transcription factor (TF) binding, the lack of a computational tool able to conduct different levels of footprinting analysis has so-far hindered the widespread applic