(2013). Transcription factor binding kinetics constrain noise suppression via negative feedback. Nat Commun 4, 1864.Grönlund A, Lötstedt P, Elf J. Transcription factor binding kinetics constrain noise suppression via negative feedback. Nat Commun. 2013;4:1864....
Model schematic for investigating the impact of nonspecific transcription factor binding on expression noise. A genome with several decoy binding sites where transcription factors (TFs) bind reversibly, is depicted. The synthesis of TFs occurs in stochastic bursts. Both the free and bound TFs are sub...
I will describe the principles and mechanisms involved in the combinatorial requirement of transcription factor binding motifs for enhancer activity, including the role of chromatin accessibility, repressors, and low-affinity motifs in the cis-regulatory code. Deciphering the cis-regulatory code would ...
within cells, such as transcription factor binding to cognate motifs, and as such, will in principle affect every gene in the same cell uniquely. There are likely many sources of extrinsic and intrinsic noise and multiple mechanisms to buffer them, (e.g. regulation of mRNA decay or protein t...
Growing evidence suggests that distal regulatory elements are essential for cellular function and states. The sequences within these distal elements, especially motifs for transcription factor binding, provide critical information about the underlying re
Fig. 1.Transcription factors in the process of transcription. Transcription factors have activation domain and DNA-binding domain. Transcription factor binds to specific DNA sequences of promoters or enhancers of genes and initiates transcription of genes with cooperation of activator, mediator, co-facto...
Context-dependent transcription factor (TF) binding is one reason for differences in gene expression patterns between different cellular states. Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) identifies genome-wide TF bin
Single-cell multiomics of the human retina reveals hierarchical transcription factor collaboration in mediating cell type-specific effects of genetic variants on gene regulation. Gene Expression Omnibus. Available from: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE247157. Chen R, De...
Two protein–protein interaction networks are shown: androgen receptor binding (for WT) and structural constituent of the nuclear pore (for 22YtoS). The line thickness corresponds to the strength of published data supporting the interaction, generated from STRING (string-db.org). Additional GO ...
A complete temporal transcription factor series in the fly visual systemNikolaos Konstantinides, Isabel Holguera, Anthony M. Rossi, Aristides Escobar, Liébaut Dudragne, Yen-Chung Chen, Thinh N. Tran, Azalia M. Martínez Jaimes, Mehmet Neset Özel, Félix Simon, Zhiping Shao,...