The results demonstrate that a binding site's strength may be uncorrelated to its functional importance.doi:10.1038/ncomms2867Andreas GrnlundPer LtstedtJohan ElfNature CommunicationsGronlund, A., Lotstedt, P. & Elf, J. Transcription factor binding kinetics constrain noise suppression via negative feed...
The genome contains several high-affinity non-functional binding sites for transcription factors (TFs) creating a hidden and unexplored layer of gene regulation. We investigate the role of such “decoy sites” in controlling noise (random fluctuations) i
Given the slow association kinetics, transcription factor mediated feedback cannot at the same time be fast and strong. Here we show that with a limited association rate follows an optimal transcription factor binding strength where noise is maximally suppressed. At the optimal binding strength the ...
Enhancement of gene expression noise from transcription factor binding to genomic decoy sites The genome contains several high-affinity non-functional binding sites for transcription factors (TFs) creating a hidden and unexplored layer of gene regul... S Dey,M Soltani,A Singh - 《Scientific Reports...
Complex formation.Two factors bind to the promoter sequences, the upstream binding factor (UBF) and the selectivityfactor 1(SL1), which contains the TBP subunit. Eventually, pol I and other initiationprotein complexesbind to those two factors. ...
which is required for Notch cleavage and activation[21]. BMP2/4 and EGF have been shown to decrease levels of the proneural bHLHtranscription factor Mash1[22,23]. Furthermore, nerve growth factor (NGF) allowed the neuronal differentiation of PC12 cells by inhibiting DNA-binding activity of th...
Moreover, combining gene expression, chromatin accessibility, and their variation driven by genetic variants in individual cell type contexts, we explained the cell type-specific regulation mechanism underlying GWAS loci, which could be related to cell type-specific trans-factor binding and chromatin ...
Two protein–protein interaction networks are shown: androgen receptor binding (for WT) and structural constituent of the nuclear pore (for 22YtoS). The line thickness corresponds to the strength of published data supporting the interaction, generated from STRING (string-db.org). Additional GO ...
A complete temporal transcription factor series in the fly visual systemNikolaos Konstantinides, Isabel Holguera, Anthony M. Rossi, Aristides Escobar, Liébaut Dudragne, Yen-Chung Chen, Thinh N. Tran, Azalia M. Martínez Jaimes, Mehmet Neset Özel, Félix Simon, Zhiping Shao,...
In all 3 models, TF binding is expected to increase transcription. However, only in the multistep model (model 2), does the TF not need to be continuously present to activate transcription. Once TFs have initiated the multistep process to start transcription, they may dissociate while ...