Human NFkB repressing factor (NKRF) is a negative regulation transcription factor, which is able to repress transcription by binding to the negative regulatory element (NRE) near the NFkB binding site in certain genes' promoters. Current researches reveals that NKRF represses ...
To explore how REV-I can downregulate SR-B1, we located transcriptional factor binding motifs on Scarb1 promoter, including that for SREBP-1. Western blotting, however, showed comparable jejunal SREBP-1 levels in LFD, HFD, and HFR groups (Fig. 5a). Although qRT-PCR showed elevated jejunal ...
In response to specific stimuli, the HIV-1 long terminal repeat (LTR) is highly activated, enhancing both transcriptional initiation and elongation. Here, we have identified a specific binding sequence of the nuclear NF-κB-repressing factor...会议名称: 46th Spring Meeting of the ...
Exogenous DJ-1 overexpression markedly decreased the EMT negative regulator KLF17, as confirmed by investigating ID-1 expression inhibition by direct binding of KLF17 transcription factor. Nagakubo et al (1997), who first demonstrated that DJ-1 is a Ras-dependent oncogene, showed that DJ-1 ...
Nourbakhsh M, Kalble S, Dorrie A, Hauser H, Resch K, Kracht M: The NF-κB repressing factor is involved in basal repression and interleukin (IL)-1-induced activation of IL-8 transcription by binding to a conserved NF-κB-flanking sequence element. J Biol Chem. 2001, 276: 4501-4508....
Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor Proc. Natl. Acad. Sci. U. S. A., 109 (2012), pp. 3167-3172 CrossRefView in ScopusGoogle Scholar [56] T. Legnaioli, J. Cuevas, P. Mas TOC1 functions as a molecular switch connecting the circadian clock...
Intriguingly, binding by importin α enhances DNA binding on the part of GAL4, implying a synergistic co-operation between these two functions. The results implicate a possible role for importin α in the nucleus additional to its established role in nuclear transport, as well as having ...
Arsenic circumvents the gefitinib resistance by binding to P62 and mediating autophagic degradation of EGFR in non-small cell lung cancer Non-small cell lung cancer (NSCLC) is characterized by hyperexpression and/or gain-of-function mutations of the epidermal growth factor receptor (EGFR), resulting...
Transcriptional coactivator with PDZ-binding motif TF: Transcription Factor tGFP: TurboGreen Fluorescent Protein TIP1: SEC twenty interacting protein 1 TRE: Tetracyclin Response Element TRPS1: Trichorhinophalangeal Syndrome 1 TUBA1C: Tubulin Alpha 1c YAP: Yes associated Protein ...
FOXD2-AS1 was significantly up-regulated in the OS tissue and cell lines. • Transcription factor HIF-1α could bind with the promoter region of FOXD2-AS1 to activate the transcription in OS cells. • FOXD2-AS1 inhibited the expression of p21 via interacting with EZH2 to silence p21 ...