TP53Gene TheTP53gene is located onchromosome 17. The Tp53 protein is a negative regulator ofcell proliferationand a positive regulator ofapoptosisinresponse to DNA damagingagents.TP53is the most common mutated gene associated with human cancer. Li-Fraumeni syndrome is a multicancer predisposition syndr...
Location 1q41 Gene Type protein-coding gene Uniprot ID Q13625 Pathway/Library others Gene Summary This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-prot...
Main Tumor protein 53 (TP53) is the most frequently mutated gene in human cancer, typically occurring as a multihit process with a point mutation in one allele and loss of the other wild-type (WT) allele1,2.TP53mutations are also strongly associated with copy number alterations (CNA) and ...
Recombinant TP53 Target Gene 5 (TP53TG5) TP53目标基因5(TP53TG5)重组蛋白 [ PROPERTIES ] Source: Prokaryotic expression Host: E.coli Residues: Tyr190~Thr262 Tags: N-terminal His and GST Tag Subcellular Location: Nucleus, Cytoplasm Purity: > 90% Traits: Freeze-dried powder Buffer formulation: ...
Gene Info — TP53 Interactomes Pathways Diseases Related Products RAB07518 TP53 recombinant monoclonal antibody, clone 4A9 RAB07542 TP53 recombinant monoclonal antibody, clone 7A9 RAB07793 TP53 recombinant monoclonal antibody, clone 16D9 RAB02727 ...
About the gene Official Symbol TP53BP2 Previous Symbol - Official Full Name tumor protein p53 binding protein 2 Synonyms PPP1R13A; ASPP2; 53BP2 Location 1q41 Gene Type protein-coding gene Uniprot ID Q13625 Pathway/Library others Gene Summary This gene encodes a member of the ASPP (apoptosis...
TP53is the most frequently mutated gene (~50%) in human cancers [44]. Although someTP53mutations lead to the complete loss of TP53 protein (mimicked experimentally byTrp53knockout mice), most are missense mutations that cause single amino acid substitutions, usually within the TP53 DNA-binding...
Mutations of the tumour-suppressor gene TP53 are the most frequent somatic genomic alterations in head and neck squamous cell carcinoma (HNSCC). However, it is not yet clear whether specific TP53 mutations bear distinct clinical and pathophysiological significance in different HNSCC subgroups.A ...
Discordant P53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract Cancer Res (1993) A. Casson et al. Discordant P53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigest...
Gene Info — TP53 Interactomes Pathways Diseases Related Products RAB07518 TP53 recombinant monoclonal antibody, clone 4A9 RAB07542 TP53 recombinant monoclonal antibody, clone 7A9 RAB07793 TP53 recombinant monoclonal antibody, clone 16D9 RAB02727 ...